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Targeted vessel ablation of type 3 uterine fibroids with magnetic resonance guided high intensity focused ultrasound

To investigate whether it is possible to manipulate perfusion in type 3 fibroids with MR-HIFU.

Safety, toxicity and immunogenicity of HPV16 E7 DNA vaccination in HPV16+ vulvar intraepithelial neoplasia grade III: a phase I study.

To study the safety, toxicity and immunogenicity of a naked DNA vaccine encoding the shuffled HPV16 E7 gene product (TTFC-E7SH) in patients with HPV16+ VINIII lesions.

Sonalleve MR-HIFU with Direct Skin Cooling: Proof of Concept Study

The primary objective of this study is to evaluate feasibility of performing MR-HIFU treatment of uterine fibroids in a Philips Sonalleve MR-HIFU system equipped with a Direct Skin Cooling device. Secondary objective is evaluation of safety.

HYSTEROSCOPIC CRYOMYOLYSIS FOR THE TREATMENT OF SUBMUCOSAL LEIOMYOMATA

The primary objective of this study is to evaluate the technical success, feasibility and safety of hysteroscopic US guided cryomyolysis procedure.

Pilot study on the influence of Sutent on tumor vascularization and necrosis in patients with renal cell carcinoma.

To observate when necrosis in metastases of renal cell cancer is occurring.

Safety, immunogenicity and clinical response of sig-HELP-E6SH/E7SH-kdel, injected in the epidermis by DNA tattoo, in HPV16-positive vulvar intraepithelial neoplasia: a phase I/II study

* To study the safety of two naked DNA vaccines encoding sig-HELP-kdel and shuffled HPV16 E6 or E7 gene products (sig-HELP-E6SH/E7SH-kdel). * To study the systemic HPV-specific immune response of sig-HELP-E6SH/E7SH-kdel.

Phase II and Pharmacological Study with Wee-1 inhibitor AZD1775 Combined with Carboplatin in Patients with p53 Mutated Epithelial Ovarian Cancer that Show Early Relapse (<3 months) or Progression during Standard First Line Treatment with Carboplatin - Paclitaxel Combination Therapy. With an additional safety and preliminary anti-tumor activity cohort of Wee-1 inhibitor AZD1775 Combined with Carboplatin in Patients with p53 Mutated Epithelial Ovarian Cancer, non-small cell lung cancer (NSCLC), sm

Objective of the phase II POP study:To determine the safety and preliminary anti-tumor activity of AZD1775 in combination with carboplatin in p53 mutated epithelial ovarian cancer in a 21 day schedule.Objectives of the additional safety and…

Ulipristal versus Gonadotropin-releasing hormone agonists prior to laparoscopic myomectomy: a double blind randomized controlled trial

Objective: to investigate if Ulipristal is non-inferior to GnRH in terms of intra-operative blood-loss (primary outcome), surgical time, surgical ease, complications, quality of life and costs.