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M17DOC: Multicenter safety, feasibility and pharmacokinetic phase I trial of ModraDoc006/r in patients with metastatic castration-resistant prostate cancer

The primary aim of this trial is to determine the recommended safe dose and schedule of ModraDoc006/r in castration-resistant prostate cancer (CRPC) patients. The first 5 CRPC patients in this study showed a different pharmacokinetic profile, as…

Evaluating Non-invasive Assessment of Staging with 68Ga-PSMA-PET/CT and 7T-MRI of Primary Prostate Cancer

Primary objective is to assess the prediction of tumour localisation, extraprostatic extension, metabolism and GS of 7T-MRI for PCa, based on anatomical, functional and metabolic imaging compared to whole-mount histopathology validation after…

Use of PSMA-PET scanning in selection for active surveillance for low risk prostate cancer

To introduce 68Ga-PSMA-PET/CT scanning in risk stratification of prostate cancer patients assumed to be suitable for active surveillance.

Data collection in Lutetium Treated Prostate cancer: Recording of Progression and Tumor Characteristics

The objective of this study is to collect data on treatment outcomes when treating mCRPC using Lu-PSMA. In addition to this, the study aims to identify correlations between biomarkers (ctDNA and CTC*s) and dosimetry data with treatment outcomes of…

An open-label, multicentre, integrated Phase 1 & 2 study to evaluate the safety, tolerability, radiation dosimetry and anti-tumour activity of Lutetium (177Lu) rhPSMA 10.1 injection in men with metastatic castrate resistant prostate cancer

This study has been transitioned to CTIS with ID 2024-511537-35-00 check the CTIS register for the current data. Phase 1• To establish the RP2D regimen by evaluation of the safety and tolerability of intravenous (IV) administration of Lutetium (…

Collection of body tissues and fluids for a biobank for prostate cancer.

Primary Objective: Establishment of an extensive PCa biobank for blood, urine, prostate tissue, lymph node tissue, and metastatic tissue in combination with clinical data, which can be used for future PCa research.

Sentinel Lymph Node Procedure in Testicular Germ Cell Tumour

Assessment of accuracy of sentinel node biopsy, defined as the false negative rate.

STHLM3 Validation Study
An observational study conducted in
[University Medical Center Groningen and the
Prostatce Cancer North Netherland Partners]
in cooperation with
Karolinska Institutet, Stockholm, Sweden

The aim of this study is to validate the effectiveness of the Stockholm3 test in the Netherlands setting with dutch patients.

A single arm phase 2 multicenter study determining the response to Cabazitaxel in metastatic prostate cancer (mCRPC) patients with AR-V7 positive circulating tumor cells (CTCs)

The primary objective of this study is to explore the PSA response to cabazitaxel in mCRPC patients who have progressed to docetaxel and have detectable AR-V7 expression in CTCs. Exploratory objectives include describing the toxicity of cabazitaxel…

SAKK 06/14. A phase I/II open label clinical trial assessing safety and efficacy of intravesical instillation of VPM1002BC in patients with recurrent non-muscle invasive bladder cancer after standard BCG therapy

The objective of the trial is to determine safety, tolerability and efficacy of VPM1002BC, in order to establish this medication as a therapy for non-muscle invasive bladder cancer in the future.

Multiparametric Ultrasound (mpUS) as Imaging Modality for the Detection and Localization of Prostate Cancer

Primary objective: To validate mpUS as imaging modality for detection and localization of prostate cancer by direct correlation of mpUS imaging and its parameters with histopathology of the resected prostate.Secondary objective: see Protocol paper,…

A Phase I-IIa, Open label, Single Center, Dose Escalating Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Intravenous Pegylated Liposomal Dexamethasone Sodium Phosphate as Monotherapy in Patients with Castration Resistant Metastatic Prostate Cancer

To determine the tolerability, pharmacokinetics and pharmacodynamics of liposomal dexamethasone (Oncocort*) in patients with metastatic prostate cancer.

Prostate Cancer Imaging with [18Flourine]Prostate Specific Membrane Antigen (PSMA) PET: a study on pharmacokinetics and test repeatability

The present study aims to:A) acquire a pharmacokinetic model of [18F]PSMA ([18F]-DCFPyl), by which simplified methods to quantify [18F]PSMA PET signal will be validated ; andB) assess the repeatability of those simplified quantitative method.

A pilot feasibility study of Dose dE-eScalaTion IN prostATe radIOtherapy with empty bladder usiNg the
MRL - DESTINATION 1B(ladder)

To develop a 5 fraction de-escalated dose SBRT protocol potentially capable of reducing side effects intended for prostate cancer patients with empty bladder