106 results
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
This study has been transitioned to CTIS with ID 2023-507230-24-00 check the CTIS register for the current data. To assess the feasibility of preserving fertility in women with 2018 FIGO stage IB2 cervical cancer with lesions measuring >2 cm…
In the RAINBO POLEmut-BLUE trial, omission of adjuvant therapy will be investigated in very low risk disease and de-escalation of treatment (observation or radiotherapy, but not chemoradiation) in low risk disease.
The main objective of the SOPI study is to select the HRD test that best predicts longest PFS on PARP-i in non-BRCA1/2 EOC patients, in order to adequately select patients that will benefit from a PARP-i. Secondary objectives are: to evaluate the 1-…
We aim to study B cells derived from tumor and peripheral blood of uterine cancer patients in order to evaluate B cell-produced (tumor binding) antibodies for potential diagnostic and therapeutic interventions.
The primary objective of this study is to determine the immune-activating capacity of treatment with pembrolizumab and carboplatin/paclitaxel in the neo-adjuvant setting of primary stage IV ovarian cancer as measured by the alteration in magnitude…
The primary objective of this trial is to determine clinical efficacy of Vvax001 in CIN3 patients.
The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…
1) What is the variation in follow-up care practice since 2011 for cervical cancer patients?2) What physician-, patient- and informal caregiver -factors are associated with differences in follow-up care schedules? Regarding patient/ informal…
3.1 Primary Objective• Feasibility of Magtrace® as a tracer in SLN sampling in early stage EOC.3.2 Secondary Objectives• Comparison of detection rate between MagTrace® and 99mTco In the general cohorto In primary staging laparotomyo In secondary…
Primary objectives: To optimize ex vivo testing procedures for cervical cancer patients derived tumor tissue tumoroids culturing from tissue from the primary tumor.To evaluate the success rate of ex vivo drug sensitivity testing for cervical cancer…
The primary objective is to gain more insight in molecular alterations in CSU by performing a broad set of molecular analysis on tissue and blood ofpatients with carcinosarcoma of the uterus and find (bio)markers which can be linked to the clinical…
The primary objective of this study is to assess the feasibility of EM-navigation for gynaecological brachytherapy catheter placement.
This study has been transitioned to CTIS with ID 2023-508722-99-00 check the CTIS register for the current data. Primary objective:- Investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer…
This study has been transitioned to CTIS with ID 2024-516736-10-00 check the CTIS register for the current data. Based on the success of the pilot feasibility study, we propose a follow-up efficacy study to explore neo-adjuvant ICB therapy as…
Primary Objectives: Determine oncologic outcomes after fertility-sparing treatment in AYAs with cervical, ovarian or endometrial cancer (Q1). Determine fertility and obstetric outcomes after fertility-sparing treatment in AYAs with cervical, ovarian…
The primary objective of the study is to estimate the clinical benefit of cemiplimab + ISA101b after progression on first line chemotherapy, as assessed by objective response rate (ORR).The secondary objectives of the study are:• To characterize the…
This study aims to evaluate the potential of growing out TIL from several patients with cervical carcinoma.
1. What is the level of psychological distress among cervical cancer patients over time?2. What is the role of characteristics of the individual, characteristics of the environment, biological function, overall quality of life, functional status and…