124 results
The aim of this study if PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of concomitant radio/chemotherapy for patients with newly diagnosed GBM is superior to MRI at 10 weeks to evaluate treatment response and to…
The objective of this study is to acquire a set of images and associated technical information to facilitate regulatory submission of the pulse sequences
Our hypothesis is that a left hemisphere tumor causes language dysfunction by mass effect on or infiltration of white matter tracts connecting Wernicke's area with Broca's area and between Broca's area and the SMA. The neurosurgical…
Primary: The major aim is to identify peptides naturally presented on glioblastoma tumors but not on healthy tissue to set up a glioblastoma specific database for potential application for immunotherapeutic aproaches.secondary: a protocol for tumor…
Does anesthesia itself or transition of anesthesia to an awake state and vice versa lead to changes in the lactate/pyruvate ratio, glucose, glycerol and glutamate concentration as measured in the brain interstitial fluid?Are the metabolic…
This study wants to evaluate on intraoperative MRI whether contrast enhancement at the borders of the resection cavity correlates with tumor tissue, and whether no contrast enhancement correlates with the absence of tumor tissue. To differentiate…
This research aims to improve quality of life of patients with high grade glioma. Psychological variables which determine quality of life in this group will be determined. By means of collecting data on several questionnaires about concerns of this…
Determine whether temozolomide given during radiation therapy followed by the combination of temozolomide and CCNU as adjuvant therapy results in an improvement in event-free survival compared to historical control cohorts.To further assess the…
To establish the safety, feasibility and quality of life in children with recurrent of progressive pontine glioma who receive a ketogenic diet during a study period of 3 months
Primary Objective is to study the anti-tumor activity of the combination bevacizumab and metronomic dose temozolomide in patients with recurrent high grade gliomas. Secondary Objective is to investigate the effects of dexamethasone and bevacizumab…
The main objective of the study is to compare the diagnostic power of Magnetic Resonance Spectroscopy, Fluorothymidine Positron Emission Tomography and conventional MRI in measuring the response of glioblastoma to radiotherapy and chemotherapy.The…
The objective of the study is to provide access to sunitinib treatment for patients who have completed a prior sunitinib study and are judged by the investigator to have the potential to benefit from sunitinib treatment. During this study the…
To determine the effect of SRT on cognition and on quality of life of patients with one to 3 brain metastases, and to relate these outcome measures with radiological changes detected on MR imaging.
Bevacizumab, Radiotherapy and Temozolomide Safety study in biopsied or resected primary GBM patients
Primary objective is determination of safety of combination of standard treatment with 3 bevacizumab infusions, followed by the standard adjuvant cycles of temozolomide. Secondary objectives: determination of: efficacy, classical response end-points…
This study investigate if, compared with the literature, an increased dosis of 70 Gy in 7 weeks will improve disease free survival against acceptable toxicity.
To determine the localisation within the primary tumor of the therapy resistant cells, before and during radiotherapy to determine the accurate boost volume. To determine changes during treatment intra- and extratumoral within the irradiated area.(…
Exploring and documenting the end-of-life phase in HGG patients: duration; residence (at home, nursing home, hospice, hospital); transfers between care settings, medical problems; palliative treatment/care; end-of-life decisions and cause of death…
The goal of this study is to improve risk stratification and treatment allocation for medium and high risk neuroblastoma patients by real time quantitative (RQ)- PCR-minimal residual disease (MRD) testing.We have recently developed a panel of RQ-PCR…
Exploring (1) cognitive functioning in WHO grade I meningioma patients, and (2) the relation between cognitive functioning and functional connectivity in this patient group.
The objective of the study is to confirm that PCNSL is positive on 89Zr-rituximab PET imaging.