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Treatment of severe hypertension in end-stage renal failure: Effect of renal denervation in dialysis patients and patients with renal transplant.

The purpose of this study is to demonstrate the effectiveness of renal denervation in lowering blood pressure in patients with therapy-resistant hypertension and end-stage renal disease who are on dialysis or who have a renal transplant.

A single arm Pharmacokinetic/Pharmacodynamic Study of Sunitinib and Pazopanib in Patients with Metastasized Renal Cell Carcinoma

The primary goal of this research is to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for sunitinib and pazopanib in patients with metastatic renal cell carcinoma, so that the possible use of biomarkers can be tested as predictors for the…

Pharmacokinetics of ertapenem in a three-weekly dosing regime in patients with end stage renal disease depending on hemodialysis

To investigate the Ertapenem plasmaconcentration time curves in a dosingscheme of three administrations per week after hemodialysis in patients with end stage renal disease depending on hemodialysis. To find a pharmacokinetic model to describe…

SoFT - Sevelamer on FGF23 Trial - A clinical trial assessing the quantitative effect of phosphate binding therapy on FGF23.

To demonstrate the feasibility to induce an effective, predictable and sustained decrease in FGF23 level in CKD stage I-IV patients, without inducing hypophosphatemia using a stepped treatment regimen aiming at restricting phosphate uptake.

MRI measurement of the effects of moderate versus deep neuromuscular blockade on the abdominal working space during laparoscopic surgery in a prospective cohort study.

The effect of deep muscle relaxation on the abdominal working space during laparosopy, measured by MRI.

The immune-response and safety of COVID-19 vaccination in patients with chronic kidney disease, on dialysis, or living with a kidney transplant

To assess the efficacy and safety of vaccination against COVID-19 in patients with CKD4/5, patients on dialysis, and kidney transplant recipients as compared to controls

DAPASALT: An Open Label, Phase IV, Mechanistic, Three-Arm Study to Evaluate the Natriuretic Effect of 2-Week Dapagliflozin treatment in Type 2 Diabetes Mellitus Patients with Either Preserved or Impaired Renal Function and Non-Diabetics with Impaired Renal Function

Primary:To investigate change in 24-hr sodium excretion during dapagliflozintreatment between Baseline (average of Days *3 to *1) and averageof Days 2 to 4 within each study group in patients withtype 2 diabetes mellitus (T2DM) with preserved or…

Long term efficacy and safety of SARS-CoV-2 vaccination in patients with chronic kidney disease stage G4-G5, on dialysis or after kidney transplantation. A prospective observational cohort study by the REnal patients COVID-19 VACcination (RECOVAC) consortium

To assess the efficacy of SARS-CoV-2 vaccination by the incidence of COVID-19 in patients with chronic kidney disease stage G4-G5, on dialysis and patients after kidney transplantation who received SARS-CoV-2 vaccination

Revised dosing recommendations of ciprofloxacin for patients with impaired renal function: a bioequivalence study.

This study has been transitioned to CTIS with ID 2024-520379-28-00 check the CTIS register for the current data. To compare exposure to ciprofloxacin between patients with impaired renal function (eGFR < 30 ml/min/1.73m2) admitted to a…

Personalized tacrolimus treatment for pediatric kidney transplant recipients by using a dosing algorithm and a once-daily tacrolimus formulation.

This study has been transitioned to CTIS with ID 2024-511585-36-00 check the CTIS register for the current data. The key objective is to personalize tacrolimus treatment for children with a renal transplant by using dosing algorithms to calculate…

Long-term outcomes in immunologically low-risk kidney transplant recipients using tacrolimus.
Extension study of: Tacrolimus monotherapy in immunologically low-risk kidney transplant recipients: a pilot randomized-controlled study.

This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…