25 results
The proposed experimental pilot study focuses on harm reduction in a specific subpopulation, i.e. in patients with schizophrenia (long-term psychotic disorder) with a suboptimal response to the currently available interventions, smoking a lot of…
Provide proof-of-concept for the hypothesis that guanfacine diminishes cognitive side-effects in ER+ BC patients treated with adjuvant hormonal therapy. Secondary, provide data for power calculations in later studies.
Primary ObjectiveThe primary objective of the study is to evaluate the effect of lemborexant 2.5, 5, and 10 mg compared to placebo on standard deviation of lateral position (SDLP) during an on-road driving test in the morning following a single dose…
The objective of this experiment is to establish the effects of tyrosine suppletion on cognitive symptoms seen in ADHD. Cognition will be assessed, while simultaneously recording brain activity.
Primary objectives: To evaluate the long-term safety and tolerability of IV administered bapineuzumab in subjects with AD.Secundary objectives: Efficacy. To explore the long-term efficacy of IV administered bapineuzumab in subjects with AD, using…
To study the feasibility of applying tDCS to APD subjects to a) influence prefrontal asymmetries and b) assess whether the restoration of prefrontal electrophysiological balances is reflected in improved social-behavioral performance.
The aim of study I is to compare the two working memory interventions, Cogmed and the intervention developed by the Bascule, in a sample of 100 children with ADHD and working memory deficits, aged between 8 and 12 years old. Effects on working…
The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…
- To investigate whether olanzapine influences the (psychomimetic) effects of THC, in particular on the Positive and Negative Syndrome Scale (PANSS) - To further explore the pharmacologic basis of the THC model - To investigate the effects of…
The main objective of this study is to determine whether THC, the primary psychoactive ingredient in cannabis, modulates activity in functional brain systems. We test this by assessing the acute effects of THC on the reward system, the working…
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
The aim of this project is to test the hypothesis that MDD patients with disturbances in anger/aggression regulation have more serotonin disturbances, as a trait marker for relapse, than MDD patients without disturbances in anger/aggression…
The main objective of the study is to find an instrument that can be used to objectively establish improvement in adults with ADHD with treatment with OROS-Mph, so that adherence to treatment can be increased and so that patients and docters can…
The Primary objective is: 1) To investigate clinical effectiveness of the glutamatergic compound memantine in paediatric patients with: - Obessive-Compulsive Disorder (OCD) GOAT-1 - Autism Spectrum Disorder (ASD) GOAT-2 with respect to symptoms of…
Objective: The objective of this study is to establish the effectiveness and safety of amantadine on emotional lability/irritability, aggression, apathy and impaired executive functioning due to frontal lobe brain injury.
In the current protocol we describe 2 work packages in which we aim to perform: A. >=2 focus-groups to gauge acceptability of the smartphone-app (WP1); B. follow-up remitted patients with recurrent MDD for 1.5 year while the background app (…
Primary Objective: The primary objective is to show that L-theanine has beneficial anxiolytic in healthy individuals. With the current experiment setup that entails the following effects of L-theanine compared to placebo:• Reduced startle effect on…
Primary Objective: To determine the effectiveness of methylphenidate in reduction of ADHD symptomatology, operationalized by personalized goals that are important to the patient and its environment, in individuals with late-diagnosed PKU. Secondary…
Primary Objective: To investigate treatment (sham rTMS/rTMS) differences in PTSD symptom severity, as measured with a clinician and self-rated instrument. Secondary Objective: To investigate the effect of rTMS and sham rTMS on general anxiety,…
Our primary objectives are to decode **signatures** of activity from the electrode that might prelude or accompany an OCD attack, by analyzing its activity in an experimental setting and in real-life situations, and to correlate symptom changes with…