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Temporal dynamics of physical activity and mood in everyday life:
Towards tailor-made interventions to prevent or ameliorate depressed mood

Primary Objective:1. To investigate, within individuals, the temporal dynamics of physical activity and depressed mood.Secondary Objectives: 2. To test mechanisms in and modifiers of the relationship between physical activity and depressed mood…

Moodbuster Light: pilot study to evaluate the acceptability and feasibility of online CBT for prevention and treatment of depression

The primary aim of this pilot study is to explore the feasibility and the usability of an innovative, combined internet and smartphone intervention for the prevention of depressive disorders among adults in the general population.

Prospective Observational Study Protocol F1J-EW-B041(a) - Development of a web-based tool for the assessment, follow-up and early prognosis of outcomes in depression

Taking into account the challenges related to treatment of MDD in a PCP setting, a MDD assessment tool for PCPs will be developed with a twofold intent: a) to help PCPs to follow the progress of their MDD patients from the start of the AD treatment…

Genetic influences on autonomic nervous system activity and the pro-inflammatory state: the moderating role of mental health status.

We will test a new theoretical model that assumes that mental health status interacts with the genetic factors influencing sympathovagal balance and the pro-inflammatory state. The results will be published in scientific magazines, and/or presented…

Factors influencing seizure threshold in Electroconvulsive Therapy

1. To determine demographic, clinical, and brain morphological and functional predictors for IST, and; 2. To examine their associations with the level of increase of seizure threshold (*ST) during the ECT course, as measured at every sixth ECT-…

Pharmacokinetics and metabolism of [14C]BMS-820836 in healthy male subjects

Primary:- to assess the pharmacokinetics of the study drug and total radioactivity (TRA) and the routes and extent of excretion of drug-derived material after administration of a single 3 mg oral dose of 14C- labeled study drug in healthy male…

SINGLE-CENTER, SINGLE DOSE ORAL EXCRETION BALANCE
STUDY OF RO5200628 IN HEALTHY MALE VOLUNTEERS

Primary:to explore the routes and rates of elimination of [14C]-radio labeled RO5200628 after oral administrationto determine the pharmacokinetics of total drug related material, RO5200628and its metabolites as appropriateSecundary:to investigate…

HEalthy LIfe in an Urban Setting (HELIUS): a prospective cohort study on health and health care utillization among different ethnic groups in Amsterdam

The general objective of HELIUS is to describe (trends in) patterns of chronic conditions across six ethnic groups over time, and to unravel the causes of (the unequal burden) of chronic diseases across ethnic groups, with an emphasis on…

Adherence of antidepressants during pregnancy

Observe the adherence rate of antidepressants during pregnancy and secondary exploration of possible factors which contribute to non-adherence

Epigenetic changes associated with ECT treatment

An observational study to test whether ECT induces epigenetic alterations of certain genes in blood lymphocytes and whether these alterations are associated with the cognitive side-effects of ECT treatment and the response to the treatment.

The long-term course of depression in primary care

There are 3 objectives:1. What are the effects of intervention on depression outcomes on the long term?2. What is the long term course of depression in primary care for patients in the control conditions?3. What are the effects of attachment on the…

Negative thinking in adolescents (young adults): differences and similarities between worrying and rumination.

The aim of this research is explaining the difference between worrying and rumination in adolescents. The following research question is investigated: On which dimensions can rumination and worrying be distinguished?For answering this question, a…

Feasibility of using a semi standardised prognostic protocol in homeopathic treatment for premenstrual syndrome/symptoms: pilot study for a pragmatic randomised trial

1. We will explore the feasibility of homeopathic treatment with a semi standardised homeopathic prognostic treatment protocol for PMS in daily homeopathic practice. 2. We will evaluate the prognostic validity of using a semi standardised prognostic…

Feasibility and effectiveness of web-based cognitive behavioral therapy for multiple sclerosis patients with co-morbid depression: a pilot study.

The goal of this research project is to evaluate feasibility and outcome of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a comorbid depressive disorder.

A single dose, open-label, randomised, cross-over bioequivalence study in healthy young men comparing two formulations of escitalopram orally dispersible tablets

Investigating the bioequivalence of the new formulation of escitalopram.

Screening for depression in palliative care patients in general practice and hospital

The main objective of this study is to determine the validity and feasibility of the Beck Depression Inventory (BDI-II), the Hospital Anxiety and Depression Scale (HADS) and a short screening (3 questions), as a screening instrument for the…

A single dose, open-label, randomised, cross-over bioequivalence study in healthy young men comparing two formulations of escitalopram: the conventional immediate release tablet and the to be marketed orally dispersible tablet

Investigating the bioequivalence of the new formulation of escitalopram.

Pilot implementation of the mother-baby intervention in the Youth Health Care

Aim : Study the effectiveness of the intervention at the new setting.Question:- Is the effectiveness of the MBI the same at the Youth Health Care as at the Mental Health CareCenters as regards the outcome measurement of the sensitivity of the mother…

Sexuality of hospital patients and their partners: a pilot study

This pilot study aims to investigate sexual wellbeing, sexual functioning and sexual health care need within four groups of patients with major illness (COPD patients, gynaecological patients, pelvic care patients, and patients with depressive…

A prospective longitudinal study to assess the relation between patient characteristics and the duration of use in patients who start Selective Serotonin Reeuptake Inhibotor treatment.

The aim of this study is to assess whether patient related characteristics assessed at the start of treatment, like beliefs and attitudes towards antidepressant treatment, determine the duration of SSRI use. Secondly, the effect of changes in…