132 results
In this project, we will conduct research within a learning and development framework to explore the barriers in adult mental health care (V-GGZ) and how and when screening and monitoring for KOPP (Children of Parents with Psychiatric Problems) can…
To investigate the feasibility of fine-grained ambulatory cortisol signaling (total 72 hours, 20 minute intervals) in individuals with depression, PTSD and healthy controls in daily life. We will investigate whether the mean peak and trough values,…
Primary Objective:Our primary goal is to investigate the feasibility of a large pragmatic study of the effectiveness of a tailored MLI for patients with depression in general practice and to evaluate potential barriers and facilitators in a process…
To replicate the DEPREDICT algorithm (formed from external cohorts/datasets) as a valid tool for prediction of AD treatment non-response, we aim to recruit 80 patients who are treat-ed with an SSRI or SNRI and are eligible and willing to have an MRI…
The primary objective of this study is to assess the long-term efficacy of COMP360 with respect to use of new antidepressant treatment, hospitalisations for depression, suicidality, and depressive severity rated using the Montgomery and Asberg…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal, neurocognitive and cardiovascular health (dependent variables) of professional…
Primary objective: Determine whether a RYGB operation causes a clinically significant decrease in AUC (area under serum concentration-time curve) of citalopram three months after surgery in comparison with the situation before the operation.…
1. Investigate whether characteristics of laboratory stress response predict depressive symptom severity measured by the Inventory of Depressive Symptomatology - Self-Report (IDS-SR) after 6 months among adults receiving treatment for depressive…
Our aim is to develop JITAIs focused on behavioral activation (BA) for depression in close collaboration with patients and therapists, and to examine their usability, feasibility, and preliminary effectiveness.
This pilot study aims to establish the feasibility of offering PCT live or online to MDD patients in remission due to rTMS by measuring treatment adherence using descriptive data and daily affect. Results will be used to improve patient compliance…
Our primary objective is to investigate whether EMDR and Imagery Rescripting are effective for individual patients who experience intrusions: patients with PTSD, patients with depression, and patients with PTSD and a comorbid depression. To this end…
Testing and implementing Stepped care 18+ in practice.
The aim of the current study is to examine the efficacy of positive CBT for the treatment of major depressive disorder in older adults. Drawing on previous findings, we hypothesize that older adults suffering from major depressive disorder profit…
Primary objective:- to determine the association of the intra-individual determinants and the physical environment in regulating lifestyle behaviour and in turn the occurrence of pre-T2D and T2D in the general population. Secondary Objective(s): -…
First aim is to quantify DA function of meso-limbic/cortical DA pathways (measured with 18F-FE-PE2I Position Emission Tomography (PET) in PD-depression with or without anhedonia (vs. non-depressed PD). Second aim is to associate these DAT findings…
The aim of this pilot study is to evaluate the feasibility of an online platform that targets depressive symptoms in an elderly population (55+) by means of an online treatment platform (Moodbuster) for depression in a pretest-posttest design.
The primary aim of the Routine Outcome Monitoring for Geriatric Psychiatry & Science 2.0 project (ROM-GPS 2.0) is 1) to evaluate treatment outcome for affective disorders in specialised geriatric mental health care and 2) to examine the…
The aim of this project is to assess the acute effects of the N-methyl-D-aspartate receptor antagonist S(+)-Ketamine compared to placebo on body and self-perception, using cognitive experimental tasks and EEG in healthy volunteers.
In the present study we aim to investigate the effectiveness of short-term schema group therapy (protocol of de Jager and Burger) on (1) persistent anxiety and depressive symptoms, and (2) dysfunctional schemas, experiential avoidance and the mode…
Primary:o To compare effort- and/or reward-related neural activity between cancer survivors and healthy controlso To assess whether cancer-related fatigue is related to effort- and/or reward-related neural activitySecondary objectives:o To assess…