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The additive effect of Imaginary Rescripting for treating depressive symptoms in childhood trauma related depression in adolescence: A multiple baseline study among 15 adolescents

The primary goal is to investigate the effectiveness of Imagery Rescripting as an add-on intervention to care as usual (CAU) for treating clinical symptoms of depression of 15 adolescents who have been exposed to childhood trauma. The secondary…

Effect of bullying exposure on immune-system related gene expression: A longitudinal twin study

Primary Objective:1)To examine whether exposure to bullying victimization in adolescence is associated with the CTRA transcriptome profile(increased pro-inflammatory gene expression and decreased antiviral and antibody-related gene expression) in…

A single-center, open-label study to evaluate the distribution, metabolism, and excretion (DME) and pharmacokinetics of MIJ821 following a single intravenous (i.v.) infusion of [14C]MIJ821 in healthy male participants.

In this study, we will investigate how quickly and to what extent the study compound MIJ821 is absorbed, transported, and eliminated from the body. For this study, MIJ821 is radioactively labelled with carbon-14 (14C). In this way, MIJ821 can be…

A Phase 1, Open Label Study to Characterize the Absorption, Metabolism, and Excretion of 14C JNJ 67953964 After a Single Dose in Healthy Adult Male Participants

The aim of this study is to investigate how quickly and to what extent aticaprant is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). For this study, aticaprant is radioactively labelled with carbon-14 (14C). In…

Selective fetal growth restriction in monoChOrioNic Twins - an inteRnAtional inveSTigation

Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…

Remote Assessment of Disease and Relapse in Major Depressive Disorder

RADAR-MDD is a clinical study aiming to assess the utility of multiparametric RMT in clinical populations with MDD. Specifically, the aims of this study are to: 1) Determine the usability, feasibility and acceptability of, and adherence to, RMT to…

Neuro-Cardiac-Guided Transcranial Magnetic Stimulation: a method to probe the depression network. Replication and dose-response.

To explore whether influence on parasympathetic activity can be used as a functional outcome measure reflecting adequate targeting of the DLPFC-sgACC network and, secondary: 1) to explore the dose-response to the intensity of the TMS output and 2)…

Optimizing treatment dosage for depression and comorbid personality disorders: a randomized clinical trial

In this study we will compare the (cost-) effectiveness on depression of 25- versus 50-sessions of psychotherapy (SPSP or ST) within one year in patients with depression and comorbid personality disorders. In addition we will examine the personality…

Effectivity and Working Mechanisms of Schema Therapy for patients with a Treatment Resistant Depression

Main research question:Does group-based schema therapy result in a reduction of depressive symptoms when comparing symptom change during the treatment to patients* baseline symptom level?Sub research questions:Does group-based schema therapy result…

LIFE: development of a personalized lifestyle intervation for patients in psychiatric outpatient care and general practice

The goal of the study is to develop a state-of-the art- lifestyle intervention that is achievable and acceptable for patients with a bipolar and severe recurrent depressive disorder. and patients in general practice with depression

Storytelling and Training to Advance Individual Recovery Skills (STAIRS): a blended module for patients recovering from depression. A pilot study.

Prior to conducting an RCT to study the efficacy of STAIRS, we conduct a pilot to (1) investigate the usability, feasibility and acceptability of the program and (2) to investigate the feasibility and acceptability of the intended measurement method…

The effect of bariatric surgery on the pharmacokinetics of venlafaxine

The aim of this study is to describe the kinetics of venlafaxine and its metabolite o-desmethylvenlafaxine after gastric bypass surgery and to compare the kinetics of venlafaxine and O-desmethylvenlafaxine before and after a Roux-en-Y gastric bypass…

A Phase 1, Open-Label, Multicenter Study to Evaluate Relative Bioavailability, Pharmacokinetics, Dose Proportionality, Food Effect After Single-Dose Administration of JNJ-67953964 (aticaprant) in Healthy Adult Participants Using reference and concept Formulations.

To evaluate the relative oral bioavailability and dose proportionality of concept formulations compared with the reference formulation of aticaprant when administered in healthy adult participants. This part will be conducted by PRA.To evaluate the…

A randomised, double blind, placebo-controlled cross-over study to investigate the effects of intravenous S(+)-ketamine on brain activation in three groups of women: healthy participants, healthy participants prone to depression and patients with fibromyalgia.

Objective 1: To determine the effects of S-ketamine on brain activation in healthy women, healthy women prone to depression and fibromyalgia patients.Objective 2: To determine the effects of S-ketamine on mood and other depression-related behavioral…

An Open-label, Randomized Study in Healthy Participants to Investigate Effects of Food (high-fat) and Repeated Administration of Itraconazole on the Pharmacokinetics of JNJ-67953964.

- To assess the effect of food (high-fat) on the bioavailability and pharmacokinetic (PK)- profile of a solid dosage formulation of JNJ-67953964.- To assess the effects of repeated QD administration of 200 mg of itraconazole (steady state) on the…

The current practice of physician-assisted suicide in psychiatry

The number of psychiatric patients who received euthanasia has grown from 0 in 2002 to 83 in 2016. Also the estimated number of requests has risen, from 320 in 1995 to 1100 in 2016. Although the numbers are relatively low and most of the requests…

Virtual Reality - Cognitive Behavioral Therapy for Depression (VR-CGT-D): The effect on depressive symptoms, automatic negative thoughts and social avoidance

The study is a first step towards investigating whether VR, and more specifically changing automatic negative thoughts (ANT) and doing role play in a virtual world, is effective in treatment of a depressive disorder.

Cohort study into Mood and Resilience in Offspring - the MARIO study

A longitudinal cohort of 550-600 children will be set up (10-25 years old, 450 children with and 100-150 children without a parent with mood disorders) on basis of already identified participants (parents) that are part of the NESDA, BiG, OPPER,…

The influence of cognitive behavioural therapy for insomnia (CBT-I) on the pathophysiology of major depressive disorder: A pilot study

The objective of the present study is to investigate the influence of CBT-I on the serum levels of MDD biomarkers pertaining to the neuroendocrine, immunologic, neurotrophic, and metabolic hypotheses of MDD (primary objective) and explore whether…

Bringing computational psychiatry to clinical practice: Patient stratification for successful administration of intranasal s-ketamine in treatment-resistant depression

Primary objective:(1) Assess baseline (i.e., before treatment) differences between esketamine-responders and non-responders on key elements of value-based decision making (including reward- and punishment sensitivity, approach-avoidance tendencies,…