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The Effects of Epidermal Growth Factor Receptor (EGFR) Inhibition on Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
A phase II controlled open-label safety and efficacy study.

The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.

The HELI pilot: clinical research to investigate the possibility of fixation of the polypropylene mesh with autologous growth factor fibrin glue in hernia inguinalis surgery.

Using AGW gives a good fixation of the polypropylene mesh in hernia inguinalis surgery and will not lead to a higher recurrence rate. The maximum acceptable recurrence rate is 10% after 3 months.

A Multi-Center, Open label, Repeated Dose Range Finding Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Efficacy of an Anti-IL-1β Monoclonal Antibody (ACZ885) Given Subcutaneously in Pediatric Subjects with Active Systemic Juvenile Idiopathic Arthritis (SJIA)

• Evaluation of the safety, tolerability and immunogenicity of subcutaneous (s.c.) administration of ACZ885 in pediatric subjects with SJIA.• Assessment of the initial efficacy profile (% responder to treatment and time to relapse) according to the…

Dose Reduction of preoperative radiotherapy in myxoid liposarcoma

To study the feasibility of reducing the dose of preoperative radiotherapy in MLS from 50Gy to 36Gy while maintaining comparable clinicopathological responses.