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Phase II trial of Linsitinib (anti-IGF-1R/IR) in patients with relapsed and/or refractory Ewing Sarcoma

Primary ObjectivesTo determine the pharmacodynamic effect of linsitinib in the tumourTo evaluate the safety and tolerability of linsitinibSecondary ObjectivesTo determine the clinical outcomeTo conduct pharmacokinetic assays with linsitinib…

Phase I clinical study of a combined modality treatment of sarcomas of the extremities or in head and neck area with radiotherapy (RT) and dose-escalation of Pazopanib

To study the safety and feasibility of adding 6 weeks of orally administered Pazopanib to 25 x 2Gy in 5 weeks preoperative radiotherapy in soft tissue sarcoma patients (to identify the Dose Limiting Toxicity (DLT) and the Recommend Phase II Dose (…

A Mechanistic Study of Mifamurtide (MTP-PE) In Patients With Metastatic And/Or Recurrent Osteosarcoma

This study was set up to examen the bioogical and radilogical efficacy of mifamurtide on metastatic osteosarcoma in order to unveil the true activity of this drug The biological activity is measured through macrophage activation. That's why the…

Extended Access of Momelotinib for Subjects with Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF)

The primary objective of this study is to provide extended access to momelotinib (MMB) and assess long-term safety in 4 cohorts of subjects who are currently receiving treatment with MMB and have not experienced progression of disease:* Cohort 1:…

International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma

This study has been transitioned to CTIS with ID 2024-516078-31-00 check the CTIS register for the current data. The objective of rEECur is to identify the optimum systemic anticancer regimen for recurrent and refractory Ewing sarcoma based on the…

Sarcomas and DDR-Inhibition; a neoadjuvant phase I combined modality study - SADDRIN-1

This study has been transitioned to CTIS with ID 2024-514907-32-00 check the CTIS register for the current data. To assess the safety and tolerability profile, in the pre- and perioperative period (up to 30 days post-surgery), of combined modality…

Phase II clinical study of concurrent Pazopanib for non-metastatic Sarcoma patients to be treated with Radiotherapy, localized in the extremities, trunk and chest wall or the head and neck region.

Primary Objective:To investigate the proportion of patients with resection specimens demonstrating induction of a pathological (near) complete remission (* 95% tumor regression)Secondary Objectives:To study tumour changes to pre-operative pazopanib…

Development of a platform of Patient Derived Xenografts (PDX) and 2D/3D cell cultures of Soft Tissue Sarcomas (STS): Protocol to obtain tumour material from patients with (non)-metastatic sarcomas.

To collect a platform of 2D/3D cell cultures (organoids) of Soft Tissue Sarcomas.To collect a platform of Patient Derived Xenografts (PDX) of Soft Tissue Sarcomas of patients with (non-) metastatic sarcomas.To study the take rate of fresh PDX tumour…

Carbon fibre reinforced PEEK versus conventional prophylactic internal fixation in patients with low grade chondrosarcoma

Objective is to compare field inhomogeinity between conventional titanium osteosynthesis and CFR-PEEK osteosynthesis on MR imaging. Visualisation of regions of interest will be scored and volume of field inhomogeneity will be calculated.