29 results
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
The goal of the *String-of-Pearls national academic biobank - the diabetes cohort* is to create a nation diabetes bio-databank, with DNA, urine and blood samples of 12.000 diabetespatients in combination with clinical data from the diabetes care in…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
PROVALID will have 3 major objectives:Primary: Determine the cumulative incidence of renal outcomes in patients with type II diabetes in different European countries. Renal outcomes are defined as:* Progression from normoalbuminuria to…
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
The primary goal of this study is to te verify that it is possible to measure te concentrations of cytokines IL-1α, IL-1RA en IL-8 in the fluid of a blister that is applied tot the skin of healthy volunteers. using cantharidin. In the future we wish…
The primary goal of this study is to obtain basal knowledge about cytokine concentration in healthy volunteers, after pressure application. In the future we wish to use this knowledge for developing a method for:1. determining a patients risk of…
Identification of genetic risk factors for development of type 2 diabetes, diabetes related diseases and complications. Furthermore the examination of the relationship between genetic variation, biochemical factors, environmental factors (obesity…
The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…
The primary objective of the proposed study is to investigate the level of physical activity among lean and obese middle-aged individuals. We hypothesize that the level of physical activity among healthy (obese) subjects is higher than in patients…
The primary goal of this study is to obtain basal knowledge about cytokine concentration in healthy volunteers, after pressure application. In the future we wish to use this knowledge for developing a method for confirming the hypothesis that in…
To assess at which level of glycemia the process of endothelial damage, represented by ROS formation and glycocalyx damage begins and to determine whether there is a glycemic threshold value for oxidative stress formation and glycocalyx damage. To…
What is the prevalence of ASB and incidence of UTIs during pregnancy in women with DM or GDM compared to pregnant women without diabetes? In addition, risk factors for ASB and UTIs, as well as consequences of ASB and UTIs will be investigated. These…
To evaluate the correlation between the findings from the explained non invasive vascular tools (CIMT, PWV, FMD and OPS imaging) with prevalent CVD in diabetic individuals.To evaluate the potential of non invasive vascular tools for identification…
In the current study we want to obtain fundamental insight in the role of insulin-mediated glycocalyx modulation as well as the effect of FFAs on this mechanism. We propose that increased levels of FFA degrade the glycocalyx and result in an…
The primary objective is to identify additional genetic loci associated with skin fluorescence in patients with type 1 diabetes Mellitus. Secondary we want to assess if the identified loci are also associated to HbA1C, or if alternative loci are…
We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…
We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…
To investigate the effects of a short term (3 months) high protein (HP) diet compared to a low protein (LP) diet in T2D patients of Caribbean and Caucasian ethnic background with regards to gut microbiota composition and production of pro-diabetic…
In this study we will confirm that a microbial intervention based on capsules containing autologous (own) lyophilized faecal matter (LFMT), taken daily for 3 month has beneficial effects on residual beta cell function (C-peptide secretion upon MMT)…