43 results
In this study we will assess the optimal analytical conditions for routine laboratory GDM screening in the Netherlands, possible discrepancies in clinical outcome due to (pre)analytical variation and the applicability of POCT testing in GDM…
To perform 31P-MRS during and after exercise using a specifically designed probe to determine variations in energy metabolism along the TA muscle in healthy humans subjects.
To standardize the procedures and analyses to support evaluation of glucose dependent insulin secretion in Type 2 Diabetes Mellitus in subjects with Type 2 Diabetes.
To investigate the time difference between the blood glucose excursion and the subsequent appearance of cerebral 13C glucose after intravenous glucose loading.
The objective of this study is to learn from young people with a chronic illness (diabetes or progressive muscular disease) who have found a balance between taking good care of their illness and having a good life. This study examines how these…
The purpose of the study is to standardize continuous glucose monitors for measuring blood glucose profiles during the day.
The objective of the study is to develop a biorepository from patients with extreme metformin intolerance to assess predictive biomarkers (clinical, genetic and genomic) of intolerance.
The aim of this study is to determine whether dopamine modifies the metabolic activity of BAT. Furthermore, we want to investigate the relation between the metabolic activity of BAT with energy expenditure and glucose tolerance in these individuals.
The presently proposed study aims to investigate how dairy proteins compare to vegetable protein and carbohydrate sources leads to glucose and insulin metabolism and substrate partitioning.
The aim of this study is the collection of clinical data to develop and test calibration, filtering and prediction algorithms to be embedded in the so-called *smart sensor* for the enhancement of continuous glucose monitoring outcomes. In particular…
The presently proposed study aims to investigate how different feeding frequencies lead to differences in glucose and insulin metabolism in impaired glucose tolerant (IGT) men.
1. To determine the nature and time course of the energy sensing machinery during starvation in humans.2. To correlate systemic adaptations with changes at the cellular level.
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
Heart rate variability in obese adolescents in relation to insulin levels during OGTT.
A pilot study
The aim of the project is to study the relation between hyperinsulinemia and changes in autonomic tone in adolescents with obesity. We have chosen to perform a pilot study, because of lack of comparable studies in the literature.
The presently proposed study aims to investigate the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning.
1) To determine the effects of caloric restriction on hypothalamic function in response to glucose ingestion in patients with type 2 diabetes mellitus.2) To determine the effects of weight loss on hypothalamic function in response to glucose…
To study cerebral blood flow with 1Tesla MRI before and after ingestion of a liquid meal.
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on PBMC whole genome expression of obese and type 2 diabetic obese subjects. Secondary objectives are to…
To study the role of central insulin on glucose metabolism.
The aim of this study is to evaluate the validity of the automated blood pressure device Colin 8800C in patients with type 2 diabetes according to the *International Protocol of the European Society of Hypertension.