48 results
To test the feasibility of breast MR elastography and explore the viscoelastic parameters of (1) normal breast tissue, of (2) breast tumours and of (3) scar tissue in the breast after lumpectomy.
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope, wire localization).The…
(1) to measure the forces resulting from typical mammographic compressions by decomposing them into a component exercised on the breast and a component exercised on adjacent body structures, (2) to determine how the proportion of these two…
To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…
Primary Objective: Examining the value of ABVS in relation to current breast imaging techniques by: - comparison of ABVS findings with MRI findings. - comparison of ABVS findings with mammography and hand-held US. Secondary Objectives: - assessment…
The aim of the research up till now was, during a number of months, to examine a total of 500 participants referred for mammography to the AMC. The different parameters which are relevant to compression were measured. Particularly the influence of…
Primary: To evaluate the effect of a dose increase to 40mg tamoxifen QD for 4 weeks in patients with at least one CYP2D6 variant allele and/or the presence of a CYP2D6 inhibitorSecondary:To evaluate the effect of concomitant use of (potential)…
Primary objective:To establish the accuracy of pretreatment 7T MRI to identify low-risk breast cancers. This will be done by identifying preoperative imaging-based characteristics related to risk factors of cancer relapse in the resection specimens…
Primary goal: determine the diagnostic quality of CE-MRI scans acquired in supine positionSecundary goal: determine the accuracy of deformable image registration between prone CE-MRI and non-CE-MRI in supine position as an alternative option
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
The primary aim of this study is to prospectively assess the incidence of pulmonary embolism in patients undergoing abdominal flap breast reconstruction.
The aim of this pilot study is to study if there is an effect on pain, QoL and the amount of breast edema of wearing a compression vest, in order to determine whether a large randomized study is feasible.
This study aims to develop a prediction rule for PMPS one year after breast surgery based on neurophysiological, psychological, and clinical parameters. Based on this prediction, individualized perioperative management and postoperative revalidation…
Primary goal: to assess the accuracy of a supine magnetic resonance imaging (MRI)-guided electromagnetic navigation system used for tumor marker implantation in breast cancer patients.Secondary goal: to assess the variability in target volume…
The PICTURE project aims to address these issues by providing objective tools, tailored to the individual patient, to predict the aesthetic outcome of local treatment. Using a combination of 3D photography and routinely acquired radiological images…
the aim of this prospective cohort study is to investigate the difference in quality of life and satisfaction with cosmetic result in patients with breast cancer undergoing breast conserving therapy surgery versus patients undergoing breast…
To evaluate the effect of HSP90 inhibition by AUY922 on VEGF by means of 89Zr-bevacizumab PET. Primary endpoint: measurement of decreased VEGF compared to baseline. A decline is defined as a decrease of at least 30% in mean Standardized Uptake Value…
To show the effect of the HSP90 inhibitor AUY922 on HER2 expression by means of 89Zr-trastuzumab PET scanning. Primary endpoint: measurement of decreased HER2 expression compared to baseline. A decline is defined as a decrease of at least 30% in…
Primary objective: To establish whether concomitant therapy of trastuzumab, bevacizumab with paclitaxel (regimen A) and/or trastuzumab and bevacizumab followed by the combination of trastuzumab, bevacizumab, and paclitaxel at progression (regimen B…
Primary:Dual-agent dose escalation part (Part 1):• To determine the maximum tolerated dose of oral, daily (qd) BEZ235 in combination with paclitaxel, qw in patients with advanced solid tumors(MTD1, Arm 1).• To determine the maximum tolerated dose of…