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A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

Early versus late insemination relative to ovulation in subfertile couples: a trial-based cost-effectiveness study.

The main objective is to determine the effectiveness of IUI-MOS, comparing the ongoing pregnancy rate of a treatment strategy comprising a maximum of four cycles of IUI-MOS when performing IUI 32-36 hours after triggering of ovulation by hCG (*late…

A double blind, randomized, cross-over placebo controlled study to investigate the efficacy of sublingual testosterone solution on physiological and subjective arousal in healthy, sexually dysfunctional premenopausal women.

Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…

The influence of laparoscopic hernia repair on male fertility

This study is a pilot study to examine the presence of antisperm antibodies after laparoscopic groin hernia repair in men. The hypothesis of this pilot study is: After laparoscopic groin hernia repair with a mesh, antisperm antibodies can be…

Impact of anti-tumor necrosis factor antibodies treatment on the semen quality of inflammatory bowel diseases patients

To study the influence of anti-TNF therapy on the semen quality of IBD patients

Pilot study: A comparison of the gold standard for measuring genital blood flow in humans with infrared thermal imaging as sex-neutral measurement

To compare the present gold standard for measuring genital blood flow in humans (for men: a mechanical penile strain gauge (Barlow-gauge) , for women: vaginal photoplethysmography) with infrared technology.

Physical therapy for premature ejaculation - a pilot study

To study the results of pelvic floor physiotherapy for premature ejaculation.

A study evaluating the pregnancy outcomes and safety of interrupting endocrine therapy for young women with endocrine responsive breast cancer who desire pregnancy

Primary objectiveTo assess the risk of breast cancer relapse associated with temporaryinterruption of endocrine therapy (ET) to permit pregnancy.Secondary objectiveTo evaluate factors associated with pregnancy success after interruption ofendocrine…

Retro-PROFIT; PReservation Of female Fertility In oncologic Treatment
Fertility, pregnancy and quality of life after fertility-sparing treatment for gynaecological cancer.

Primary Objectives: Determine oncologic outcomes after fertility-sparing treatment in AYAs with cervical, ovarian or endometrial cancer (Q1). Determine fertility and obstetric outcomes after fertility-sparing treatment in AYAs with cervical, ovarian…

Neuromodulation of the Dorsal Genital Nerve in Patiënts with Persistent Genital Arousal Disorder

The primary aim is to investigate the effect of neuromodulation (via UCon) on the symptoms of patients with PGAD. The hypothesis we want to test is whether neuromodulation of the DGN reduces the severity of symptoms of PGAD.

Male fertility after treatment with radioiodine for differentiated thyroid carcinoma

By means of this study we want to make statements regarding the effects of (high dose) radioiodine on male fertility, depicted by various fertility parameters (serum endocrine markers (LH and FSH), semen analyses and (conceived) pregnancy (outcomes…