45 results
Primary Objective: • To investigate the difference in localization of the lesioned area in the brain towards the preoperative assessed target and relate this to registration and rating of clinical tremor.• To investigate the role of the dentato-…
Our primary objective is to identify the disturbances in prosody, phonation and articulation with which dysarthria can be automatically recognized in speakers of Dutch, and German. To this end, we will first perform an experiment that involves the…
Objective: The primary objective of this study is to investigate whether pain experience decreases or increases when cognitive functions decline in patients with Parkinson's disease. Furthermore will be investigated whether this is influenced…
The main purpose of this research is to assess the interrater reliability (3 raters) of an instrumented clinical spasticity measurement. Also, the agreement will be determined between the instrumented and non-instrumented spasticity measurement.…
The main objective of this study is to evaluate whether the PowerGlove is a valid instrument that can be used for the assessment of hand motor symptoms in patients with Parkinson*s disease. Sensitivity, specificity, intra-examiner reliability and…
The aim of the study is to investigate the differences in multi-joint coordination between healthy young and healthy elderly. Secondly, we want to study adaptation of ankle and hip strategy with the application of whole-body force fields and…
- To investigate whether the effect of early-start rasagiline treatment (according to the ADAGIO study protocol) provided long term benefits over delayed-start.- To investigate the long-term effects of rasagiline in PD subjects who participated in…
The present study aims to assess sensory weights and reweighting in healthy elderly and elderly with polyneuropathy, visual impairments or balance disorders compared to young healthy adults.
The aim of the study is to generate a validated questionnaire to measure dysphagia in the three different stages of Huntington's disease.
The general aim of this study is to explore how a motivational deficiency (i.e. apathy) related to neurodegenerative diseases is associated with effort and how it can be distinguished from intentional underperformance. We will investigate whether…
To assess whether there are differences (including sensitivity and specificity) in pen motion and grip force patterns, derived using a system for handwriting monitoring while performing different writing, tracing and fine motor skill tasks, between…
The development of a valid and reliable test intended to measure functional motor activities in daily life of children with DCD.
The main goal of the proposed experiment is to provide evidence for the hypothesis that the adaptation range of posture control behaviour with only proprioceptive feedback is similar to the adaptation range with visual and tactile feedback also…
To investigate the value of ancillary diagnostic investigations, more specific MRI, 123I-MIBG scintigraphy, ultrasound examination of the basal ganglia and analysis of cerebrospinal fluids to differentiate Parkinson's disease and the Atypical…
In the proposed experiment we expect to find a similar functional segregation within prefrontal and premotor cortical regions when a free choice option is introduced.
The primary objective of this study is to assess the reliability and validity of the most commonly used anxiety rating scales in PD within one year. In the event that none of these scales has satisfactory clinimetric properties, additional…
We aim to experimentally evoke FOG in patients walking on a motorised treadmill, using either expected or unexpected obstacles, or changes in visual feedback of gait
To demonstrate the likelihood of the motor causes of drooling in PD: reduced swallowing frequency (akinesia), open mouth and mouth breathing (rigidity), reduced swallowing capacity (hypokinesia) and stooped posture.
Since obstacle avoidance is impaired in PD, with the inability of the patient to regulate both cadence and step length before crossing the obstacle, we wonder what the effect of controlling cadence (by means of a metronome) will be on the pattern of…
The ultimate goal is to build a large, well-documented, database of normal FP-CIT data obtained in healthy volunteers. For this purpose, in a large number of European institutes we will obtain in, minimal 10 and maximal 15 healthy volunteers per…