43 results
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
Primary objectives:The primary objectives of this trial are:• To show PK similarity of BI 695500 to MabThera® and Rituxan® and of Rituxan® to MabThera® (three-way PK similarity).• To establish statistical equivalence of efficacy of BI 695500 and…
(1) To determine the frequency of antibody-mediated encephalopathy in children with seizure-related or (sub)acute onset neuropsychiatric disorders. (2) To identify the target auto-antigens of selected seizure-related and (sub)acute onset…
(1) To determine frequency of antibody-mediated encephalopathy in adults with new-onset epilepsy/status epilepticus or chronic epilepsy. (2) To assess outcome of antibody-mediated encephalopathy in adults with epilepsy, and identify markers for good…
The objective of this project is to collect fresh human bone marrow and to process this bone marrow to an intended product in a short time to enable the use of this product in the acute phase of a disease/disorder/lesion of the central nervous…
Primairy objectivesTo study the pharmacokinetics (plasma and cerebrospinal fluid) of meropenem in infants <= 90 days of postnatal age with probable or confirmed bacterial meningitis (BM); To describe the safety profile of meropenem in the…
Aim of this proof of principle study is to develop a reliable and safe application of bilateral FES of the calf muscles to facilitate insufficient push-off in patients with MS and to assess the preliminary effects of FES on net ankle power…
*To examine the (longitudinal) association between long term clinical outcomes in MS and pathology occurring in brain grey matter, spinal cord grey matter and brain lesion load.
1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.
To evaluate the incidence, causes and characteristics of meningitis and/or encephalitis in patients of all ages:1. To determine the causes of meningitis and/or encephalitis in children and adults2. To evaluate the clinical signs and symptoms and CSF…
The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…
Primary objective:* To analyze the association between single nucleotide polymorphisms (SNP) markers and treatment response. Treatment response is based on the Expanded Disability Status Scale (EDSS) progression and relapse outcomes over the first 2…
Primary: The primary objective of the study is to assess the effect of long term treatment with prolonged release fampridine 10 mg twice daily on the physical component scale (PCS) of the Short Form (36) Health Status Questionnaire (SF 36) as…
The overall objective of this trial is to provide additional data on the factors influencing IFN-beta response.Primary· To analyze the association between single nucleotide polymorphisms (SNP) markers and Rebif and Copaxone treatment response.…
The purpose of this study is to determine if SAR153191 150 mg once a week (qw) SC (subcutaneous) administration is safe and effective in reducing the recurrence and symptoms of ankylosing spondylitis over a long period of time (up to 5 years).
The primary objective of this study is to determine the prevalence and degree of cognitive complaints and impairment of patients with MS. Secondly we want to determine the relationship between age, gender, clinical type of MS and disease progression…
The objective of the study is to estimate the prevalence of anti-JCV antibodies in MS patients,including the following criteria:* Age* Gender* Race* Country of birth and the duration of residence* Current country of residence and the duration of…
The goal of this research project is to evaluate feasibility and outcome of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a comorbid depressive disorder.
The primary objective of the trial is to study the efficacccy of sirolimus in paraneoplastisch neurological syndromes associated with anti-Hu antibodies (Hu-PNS)Secondary objectives are to correlate clinical improvement with anti-Hu antibody titers…
The purpose of this study is to investigate the association between T cell compartment composition and vitamin D status in MS patients, with particular interest for regulatory T cell functionality.