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Early psychological intervention in stroke patients independent in activities of daily living to reduce symptoms of anxiety and depression of influence on long-term functional outcome.

Primary: to determine whether an early psychological intervention poststroke in order to reduce symptoms of anxiety and depression, is feasible.Secondary: To evaluate if an early individual psychological intervention in patients independent in…

The effect of cervical transcutaneous electrical neurostimulation on cerebral blood flow velocities, cerebral vasospasm and ischemic deficit in secondary cerebral vasospasm after subarachnoid haemorrhage

To find out if patients with secondary cerebral vasospasm after SAH can benefit from cervical TENS.

The long-term effects of an implanted drop foot stimulator (ActiGait®) on walking capacity in patients with stroke

The main goal of this study is to evaluate the functional efficacy of the Actigait® system as a FES device, as well as its training effects with regard to (complex) walking. In addition, with regard to the training effects of FES, we intend to…

Intensive five day intravenous insulin treatment combined with enteral feeding in hyperglycemic ischemic stroke patients: a feasibility study

To optimize a safe five-day intensive intravenous insulin treatment post stroke and to assess glucose profiles in patients with stroke and HG on admission, receiving standard continues enteral tube feeding.

The use of helium after resuscitation: a safety and feasibility study

The objective of this trial is to investigate the feasibility and safety of helium ventilation post cardiac arrest.

Effect of different types of ankle foot orthoses on weight-bearing and static and dynamic balance contribution of the paretic and non-paretic leg in stroke patients.

- What are the effects of different types of ankle foot orthoses on weight-bearing and static and dynamic balance contribution of the paretic and non-paretic leg in stroke patients? - What are the effects of different types of ankle foot orthoses on…

Adult mesenchymal stromal cells to regenerate the neonatal brain: the PASSIoN trial (Perinatal Arterial Stroke treated with Stromal cells IntraNasally)

This study will investigate whether bone marrow-derived allogeneic MSCs, as administered by the nasal route, can induce the formation of neuronal tissue and restore brain function in neonates who suffered from perinatal arterial ischemic stroke (…

Effects of Non-invasive Transcranial direct current stimulation on posturographical and neurophysiological parameters in healthy and stroke.

To determine the instantaneous effects of cerebellar tDCS during PFT on posturographical and neurophysiological parameters in stroke patients and healthy subjects.

Continuous glucose monitoring in acute ischemic stroke:
a prospective study of the feasibility of continuous glucose monitoring and evolution of glucose in acute ischemic stroke patients suitable for endovascular treatment

We aim to assess the feasibility of continuous glucose monitoring with CGM in patients with acute ischemic stroke who are eligible for endovascular treatment. In addition, we will assess the evolution of glucose levels in these patients.

Adult mesenchymal stromal cells to regenerate the neonatal brain: the PASSIoN trial (Perinatal Arterial Stroke treated with Stromal cells IntraNasally)

This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, as administered by the nasal route, in neonates who suffered from PAIS. The ultimate goals of the present study is therefore to develop a therapy using adult human…

Interaction between the brain hemispheres - key to motor recovery after stroke (InterAct)

The aim of this study is to determine whether cTBS treatment of the contralesional primary motor cortex leads to a reduction in contralesional inhibition from the contralesional to the ipsilesional motor cortex during movement onset.

The effect of ischemic preconditioning in patients with cerebral small vessel disease

To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…

Clear-Brain: A partial randomised clinical trial investigating stimulation of the glymphatic system by either deepening sleep with lower-sodium oxybate or inhibiting cortical spreading depressions with non-invasive vagus nerve stimulation, or both, in patients with Cerebral Amyloid Angiopathy (CAA).

Objectives:The main objective will be to assess whether treatment with nVNS, LXB or both interventions will increase the clearance of Aβ from the brain, compared to pre-treatment, in patients with CAA. Second objective is to study whether CAA…