9 results
The main objective of this study is to investigate if the occurrence of cognitive impairment and functional reorganization *defined as increased functional activation in cognitively preserved patients- in MS can be explained by changes in GABA and…
Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
The objectives of this initiative are:1. To establish the disease oriented biobank; processing and storage of blood and CSF specimens and health information of MS patients (which may include health records, family history, lifestyle and genetic…
Primary Objective: The primary aim of this proposal is to identify miRNA profiles that can be used as novel MS biomarkers and to design a test, based on these profiles, that can be used in clinical practice.Key objectives are:(1) deep-sequencing of…
Measures of cerebral perfusion and cerebral metabolism will be compared between patients with different disease courses of MS and healthy controls.Hereby we wish to answer the following questions:- Are cerebral energymetabolism and cerebral…
Primary objectives:To prospectively assess longitudinal changes in Proteolipid Protein 1 (PLP1) and additional disease-related biomarkers in cerebral spinal fluid (CSF) and blood and evaluate their utility in support of the development of therapies…
The primary objective of this study is to assess whether the cause of neurological deterioration in patients with RRMS/CIS is a real relapse, a pseudo-relapse or mimic and compare these groups on baseline characteristics. Secondary objectives: * To…
In this pilot study, we aim to investigate if increasing field strength beyond 7T will result in additional advantages in characterization of MS lesions in vivo and to identify its limitations and technical challenges. More specifically, firstly, if…
To investigate wether it is possible to distinguish PPi from PPn early in the disease course of PPMS, by use of different radiological and biological markers.