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A Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on
Seizures and Behavioral Symptoms of Multiple Individually Titrated Doses of Radiprodil
in Children with GRIN-related Disorder.

This study has been transitioned to CTIS with ID 2023-509672-42-00 check the CTIS register for the current data. Primary Objective:-To determine the long-term safety and tolerability of multiple individually titrated doses of radiprodil as an addon…

Multicentre, Open-label, Randomised Study to Assess the Diagnostic Value of Amyloid PET
Imaging in Patients with Subjective Cognitive Decline Plus, Mild Cognitive Impairment, or Dementia
Where Alzheimer*s Disease Is in the Differential Diagnosis (Diagnostic and Patient Management
Study)

This study (AMYPAD Diagnostic and Patient Management Study) will determine in a real-life clinical setting for whom diagnostic amyloid PET imaging is appropriate, when this is best performed, and how the resulting information is influencing…

A MULTICENTER, OPEN-LABEL, SINGLE-ARM STUDY TO EVALUATE THE PHARMACOKINETICS, EFFICACY, AND SAFETY OF BRIVARACETAM IN NEONATES WITH
REPEATED ELECTROENCEPHALOGRAPHIC SEIZURES

This study has the purpose to assess the pharmacokinetic (the science determining the fate of substances administered to the human body), safety and efficacy of brivaracetam (the study drug) in neonates who have seizures that are not adequately…

Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) study;Addendum ancillary study:
Inflammation, endothelial dysfunction and macro- and microvascular flow in acute decompensation of of cirrhosis and acute-on-chronic liver failure

The aim of this study is to assess prospectively the critical period prior to the development of ACLF (1), to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF (2) and to identify the…

Perioperative assessment of cerebral ischemia in patients undergoing aortic arch surgery

The primary objective is to measure the dose of cerebral ischemia, as a measure of cerebral hypoperfusion, before, during and after aortic arch surgery. Secondary objectives include parameters that influence the occurrence of cerebral ischemia (…

TIBOHCA: A phase II study to evaluate the safety, tolerability and pharmacokinetics of 2-Iminobiotin (2-IB) after out of hospital cardiac arrest

The primary objective of this study is to evaluate the short term safety and tolerability, and pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Secondary objectives include safety and efficacy parameters at 30 days…

Validating in vivo quantification of tau with [18F]AV-1451 PET

This protocol is a follow-up of a previously submitted protocol (Evaluation of [18F]AV-1451 kinetic modelling in patients with Alzheimer*s Disease and healthy controls, protocol nr. 2014.519), in which the optimal (simplified) kinetic model for [18F…