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A Clinical Study of Two Doses of a Selective p38 MAP Kinase Inhibitor, VX-745, to Evaluate the Effects of 12-Week Oral Twice-Daily Dosing on Amyloid Plaque Load as Assessed by Quantitative Dynamic 11C-PiB Positive Emission Tomography (PET) Amyloid Scanning

The primary objective is to assess the effects on amyloid plaque burden of administration of VX-745 for 12-weeks, as assessed by Dynamic 11C-PiB (Carbon-11 labeled Pittsburgh Compound B) PET Amyloid Scanning in patients with Mild Cogntitive…

A Biomarker Study to Measure CSF Proteins Upon Application of an Indwelling Lumbar Catheter for 36 Hours in Subjects with Mild Cognitive Impairment or Alzheimer*s Disease

Primary ObjectiveTo investigate changes of CSF proteins over time using continuous CSF sampling for 36 hours, including but not limited to A*1/x-42, A* 1/x-40, A* 1/x-38 and A* 1/x-37 in subjects with MCI or AD. Secondary Objectives1. To investigate…

Determinants of successful discontinuation of antipsychotics used for behavioural symptoms in people with intellectual disability

To investigate whether the occurrence and severity of neurological withdrawal symptoms during a discontinuation trajectory of antipsychotics used for challenging behaviours in people with intellectual disability is associated with achievement of…

Effects of exposure to environmental chemicals on development during adolescence

The aim of the study is to determine whether prenatal and current exposure to environmental chemicals is associated with developmental outcome in adolescents. We will investigate whether this exposure is associated with the thyroid hormone…

Understanding of malnutrition in people with complex multiple disabilities.

The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…

Treatment of central pain syndromes by caloric vestibular stimulation

Objective of the study: With this pilot study we attempt to explore the possibility to treat patients suffering from intractable neuropathic pain with CVS

Genetic and epigenetic networks in cognitive dysfunction

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An open-label study to evaluate the long-term safety and tolerability of AFQ056 in adolescent patients with Fragile X Syndrome

PrimaryTo evaluate the long-term safety and tolerability of AFQ056 in adolescent patients with FXS as assessed by:* Incidence and severity of adverse events and serious adverse events* Changes in vital signs, laboratory assessments, and ECGs*…

A randomized, double blind, placebo-controlled crossover study to investigate the effects of a selective serotonergic reuptake inhibitor on resting state fMRI in heathy volunteers.

We propose to conduct a study in healthy subjects where a serotonergic challenge is given in a placebo-controlled, crossover fashion. Before each challenge, participants will be measured 1 time to define their baseline resting state networks (RSNs)…

Creation of a disease model system to investigate the mechanisms causing intellectual disability.

1) to gain insight in the pathophysiological mechanisms leading to intellectual disability and 2) to create a model system which allows screening of therpeutic interventions for efficacy.

An open-label, one-sequence crossover interaction study investigating the effect of multiple doses of Lu AE58054 on cytochrome P450 3A4 and 2D6 activity measured by midazolam and dextromethorphan pharmacokinetics in healthy young men

To study how the registered medicine Midazolam is absorbed, broken-down and excreted by the body after or without administration of multiple doses of the test compound.To study how the registered medicine Dextromethorphan is absorbed, broken-down…

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

Neurofeedback as a remediation for late neurocognitive sequelae in survivors of childhood brain tumours: a pilot study

The aim is to study if Neurofeedback can be an applicable intervention.for survivors of childhood brain tumours. The QEEG wil be investigated whether under or overactive brainareas exist which can be trained. This study will also investigate whether…

Diagnostics and diagnosis oriented research of mental retardation of unknown cause

The main objective of the study is to reach an etiological diagnosis in as many cases of a selected group of MR patients. The aim is to do so in at least 15-20% of hitherto unexplained MR.Also an objective is the establishment of a genetic-…

A 12-month Longitudinal, Prospective, Observational, Natural History Study of Patients with Sanfilippo Syndrome Type A (MPS IIIA)

1. Primary Objective(s) The primary objective(s) of this study are to:* Evaluate the course of disease progression in patients with MPS IIIA who are untreated with any investigational products to inform possible future treatment studies * Determine…

Open-label, non-randomized, multi-centre positron emission tomography (PET) imaging study to evaluate a single dose of 250 MBq BAY858102 ([F-18]DPA-714) for its diagnostic potential in discriminating patients with probable Alzheimer's disease from healthy volunteers and to evaluate the radiation dosimetry of a single dose of 150 MBq BAY858102 ([F-18]DPA-714) in healthy volunteers

Based on the scientific background and knowledge as detailed above this clinical proof-of-mechanism study is performed in order to determine if PET imaging with [18F]DPA-714 has the diagnostic potential to discriminate probable AD patients from…

Robotic toys within occupational therapy for children with developmental disabilities.

Objective:This study has as its aim to examine the short-term effect of a robotic-facilitated play therapy within occupational therapy on the level of playfulness of children with developmental disabilities aged 2-16 years.

Amyloid pathology in the diagnosis and treatment of cognitive decline and dementia in patients with Down syndrome.

To investigate the relation between the amyloid metabolism (as measured by plasma Abeta1-40 en 1-42) and the incidence of dementia in DS patients and the investigate whether there is interaction with vascular or genetic factors with respect to this…

Transporter defects; a study of novel mechanisms of thyroid hormone resistance with dramatic consequences.

Our project focuses on the function of transporters and deiodinases in the (dys)regulation of intracellular T3 levels in patients with psychomotor retardation and abnormal serum thyroid hormone levels. The main objectives of our study are:1. To…

Creatine transporter defect in females.

1. Define the clinical spectrum in female carriers of creatine transporter defect. 2. Correlate the clinical phenotype with X-inactivation studies.