84 results
Primary Objectives: To formulate answers to the following questions:Three main study objectives will be examined in the present project.1. What are the employed coping strategies in patients with refractory epilepsy and how do these develop over…
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
The purpose of the study is to investigate the pharmacokinetics of S 44819. S 44819 is labeled with 14-Carbon (14C) and is thus radioactive (also called radiolabeled). In this way, S 44819 and its metabolites can be traced in blood, urine and feces…
The current study will examine psychological predictors of fluctuations in mood in the daily life of patients with CM. First, we will examine the role of within-subjects factors (headache, goal disturbance, rumination) in explaining daily…
Primary objective:1. To investigate the clinical value of [18F]Flutemetamol PET in memory clinic patients and especially those with suspicion of young onset dementia in terms ofa. change in (level of confidence of) diagnosis;b. impact on patient…
In this study the potential of using the enhanced procedures for analyzing diffusion weighted data which were acquired according to clinical procedures is further investigated. The result is compared to the reconstruction of the OR based on high…
To develop and examine the test-retest reliability of a wheelchair skills test for children
The purpose of the study is to investigate how quickly and to what extent the study medication is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will…
The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.
In PD patients: To investigate the effect of Levodopa on postural responses after translational perturbations. These outcomes will be helpful to decide whether patients in the cohort study should be measured in the ON or OFF medication state. In…
* To examine how multiple oral doses of the test compound (an experimental medication) will be taken up by the body, metabolized and excreted by the body in combination with the oral contraception pill which consists of ethinyl-estradiol and…
The purpose of this open label extension study is to gather further compliance and safety information on the longer-term (up to approximately 48 weeks) use of the study product. This will provide valuable information in addition to the findings of…
Primary: Safety and tolerability of fingolimod 0,5 mg in a broader population of MS patients.Explorerend: incidence of macular edema, bradyarrythmia, Patient-Reported Outcomes Indices for Multiple Sclerosis (PRIMuS) and Short Form Health Survey*12 (…
Main objective is to study changes in in vivo blood viscosity during mild therapeutic hypothermia and rewarming in patients after cardiac arrest. Secondary objectives are to study the effects of cooling and rewarming on-Hemodynamic parameters-…
The main object of this study is:Optimization of the face-name association task, such that this task can be used to examine the prediction of postoperative memory failure in preoperative patients with epilepsy.Sub Objectives:- Investigation and…
- to assess the excretion balance of total radioactivity in urine and faeces after single oral dose of 20 mg 2.35 MBq (64 µCi) of [14C]-S 47445, - to determine the pharmacokinetics of the total radioactivity in whole blood, plasma and urine after…
In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
In this study we want to monitor the neurological complications occurring during hip operations, consisting of hip arthroplasty ('head-neck' prothesis) for traumatic hip fractures. We want to establish that there is more understanding of…
To develop reliable and feasible aerobic and anaerobic exercise tests for children with spastic CP who use wheelchairs.
The objective of this study is:• To investigate the safety and tolerability of 30 h continuous CSF sampling in healthy male subjects• To evaluate subject experiences of continuous CSF sampling using a standardized questionnaire.• To gain experience…