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Spinal Cord Stimulation in Small Fibre Neuropathy: A pilot study

This study is a pilot study to investigate whether Spinal Cord Stimulation (SCS) combined with best (drug) treatment as usual (TAU) leads to clinically significant pain relief in patients suffering from pain in the lower limbs due to SFN, defined as…

A Phase I, drug-drug interaction study between oral doses of GLPG1205 and an OCT2 probe substrate (metformin) or a BCRP probe substrate (rosuvastatin) in healthy male subjects

PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…

Subcutaneous immunoglobulins with rHuPH20 in multifocal motor neuropathy

To study whether hyqvia is as effective, safe and tolerable (or more tolerable) as IVIg.

STOP NEUROMA
Surgical Treatment Of symPtomatic NEUROMA:
Open non-randomized clinical investigation to evaluate the safety and effectiveness of the nerve capping device to prevent neuroma formation after traumatic nerve section

Primary clinical investigation objectives[Safety]The primary safety objective of the clinical investigation is to provide data that demonstrates safety of the device, defined as < 8.3% serious adverse device effects, up to 6 weeks following…

A single-center, open-label, single oral dose study to investigate the absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetics of EMA401 after a single dose of [14C]EMA401 in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent EMA401 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). EMA401 will be labeled with 14-Carbon (14C) and is…

Rotterdam Observational Study in CIDP of Pharmacokinetics of Intravenous γ-globulin

The main objective of the study is to determine the PK and PD of IVIg during maintenance treatment in patients with CIDP. These data will be used to conduct a NONMEM analysis in relation to the dosage, frequency and batch of IVIg used. The secondary…

Development of a nociceptive test battery - inflammatory and neuropathic pain tests.

* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.* Investigation of confounding factors including anxiety, personality, and subject sex.* Explore logistics,…

A study to investigate the pharmacodynamics, safety and tolerability of cutaneous capsaicin in healthy adult subjects.

-To investigate the feasibility, applicability, safety, tolerability, and reproducibility of addition of the capsaicin-heat model and the thermal grill to the existing nociceptive pain test battery in healthy subjects.-To investigate the feasibility…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

ARA 290 Intravenous-Subcutaneous crossover study in normal human volunteers - PKARA Study

To measure the PK of ARA290 when given in de SQ form

A multicenter, Single arm, Open label study of The Repeated Administration Of Qutenza For The Treatment Of Peripheral Neuropathic Pain.

The purpose of the study is to assess the safety and efficacy of repeated treatments of QUTENZA in subjects with peripheral neuropathic pain.

Development of a nociceptive test battery - acute pain tests

Primary Objective* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.Secondary Objectives* Investigation of confounding factors including fear of pain, mood, age and…

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Intravenous versus Subcutaneous Immunoglobuline therapy in Multifocal motor neuropathy

1. Primary objective:To evaluate whether subcutaneous immunoglobulin infusion is as effective as intravenous immunoglobulin in maintaining muscle strength in patients with multifocal motor neuropathy.2. Secondary objective:a) To evaluate whether…

Treatment of Complex Regional Pain Syndrome type I;A randomised, double-blind, placebo-controlled study with multiple rounds of S(+)-ketamine infusions (The Ket Ket Study)

Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…

The kinematics and kinetics of walking using a forefoot offloading shoe in patients with diabetes and periferal neuropathy.

The goal of this study is to compare the kinematics and kinetics of walking in a FOS with a standard shoe in diabetic neuropathic patients.

Efficacy of a thumb opponens splint on manual dexterity in patients with Hereditary Motor and Sensory Neuropathy: a pilot study

Purpose of this study is to assess the feasibility, tolerability of a short thumb opposition splint and the initial efficacy of this splint on manual dexterity and perceived limitations in activities in patients with HMSN1a. Additionally, the…

Multicenter, open*label, phase II study in patients with monoclonal
gammopathy of unknown significance (MGUS) and anti Myelin Associated
Gycoproteine (MAG) Neuropathy and Zanubrutinib Treatment * MAGNAZ trial

Main objective:To improve the functional neurological outcome of patients, as measured on the Raschbuilt Overall Disability Scale (RODS) for inflammatory neuropathies (iRODS) with Zanubrutinib in combination with standard treatment with Rituximab or…

Magneto-encephalography (MEG) to image modulation of brain activity by Spinal Cord Stimulation (SCS) treatment in chronic pain patients, an explorative study.

Use Magneto-encephalography (MEG) to image the cortical and thalamic effects that underlie the analgesic effects of SCS for chronic pain patients. To analyse the differences in cortical and thalamic activity between SCS ON and SCS OFF.

Feasibility of Self-treatment of Painful Diabetic Neuropathy using Electrical Vasomotor Nerve Stimulation,

Determining the feasibility of EVNS performed at home by the patient and/or caregiver, after instruction from the podiatrist.