25 results
The primary objective of the study is to evaluate the effect of macitentan on right ventricular and hemodynamic properties in patients with symptomatic PAH.Secondary objectivesTo evaluate the safety and tolerability of macitentan in patients with…
Primary Safety Objective * Proportion of patients who complete 24 weeks of combination treatment on pirfenidone at a dose of 1602*2403 mg/d and nintedanib at a dose of 200*300 mg/d Secondary Safety Objective * Proportion of patients who discontinue…
To assess the percentage of COPD and asthma patients correctly (all critical items correct) using the Accuhaler/Diskus vs Elpenhaler inhaler devices after reading the package insert. Also satisfaction with and preference for an inhaler will be…
Primary:* To describe the effect of the new thermo stable formulation of FLOLAN on quality of life in patients switching from the currently marketed FLOLAN to the new thermo stable formulation.* To determine the dose titration requirementSecondary…
To investigate the effects of beclomethasone plus formoterol (in a single inhaler) versus single agents formoterol and beclomethasone dipropionate pMDI with HFA-134a propellant and placebo on the airway responses to allergen challenge. The primary…
The main objective of this study is to determine if Low-Flow is non inferior in reducing apneic spells compared to caffeine. Secondary objectives are investigating if these treatments have an effect on the need of supplemental ventilation and on the…
In this research we want to determine whether patients prefer the ProTrach DualCare over other speaking valves, if it improves quality of life, compliance with HME use and lung function.
Primary objective: To show that the variability of whole blood total and unbound plasma tacrolimus concentrations during the first 6 days post transplantation is larger than the variation of tacrolimus concentrations in stable clinical situation.…
To compare quality of life, cost-effectivenessand number of dissected mediastinal lymph node as a derivative oncologic outcome between open- and VATS lobectomy.
This study aims to investigate if there is a correlation between the severity of bronchoconstriction after an exercise challenge test 6h after a single dose of Qvar and after 4 weeks of treatment with Qvar, in order to know if the respons to a…
n.v.t.
The primary objective is to determine whether treatment of acute intermediate-risk PE (as defined by the inclusion and exclusion criteria) with parenteral anticoagulation for at least 72 hours after diagnosis, followed by dabigatran over 6 months,…
Research question and objectives: To explore whether genetic/genomic markers (alone or combined with clinical covariates) could be used to predict OS in NSCLC patients treated with Vargatef® according to the approved label.
The primary objective of the study is to evaluate the diagnostic accuracy of a CTEPH screening program based on the stratification score and the *rule out criteria*.To prospectively assess the feasibility and cost-effectiveness of the CTEPH…
To further research nintedanib PK and correlate them with clinical parameters and toxicity. Results could be used to optimize treatment of nintedanib in the future by dose individualization based on patient*s characteristics or therapeutic drug…
Objective of the study: Primary objective: to determine whether early discharge and out-of-hospital treatment of patients with low-risk acute PE (as defined by the inclusion and exclusion criteria) with the new oral factor Xa inhibitor rivaroxaban…
Primary objective:To compare the proportion of participants who make at least one critical error after reading the section on inhaler use in the patient information leaflets (PILs) for ELLIPTA and BREEZHALER inhalersSecondary Objectives:To compare…
Primary objective: to investigate MPA exposure in a variety of autoimmune diseases in stable treated patients. Secondary objective: to develop predictive exposure models and evaluate the influence of population covariables on pharmacokinetics .The…
Main objective:To assess the effects of selexipag on right ventricular (RV) function in participants with PAH.Secondary objectives:- To further assess the effects of selexipag on RV function using MRI.- To assess the effects of selexipag on disease…
The objective is to investigate if there is a flow-dependent effect of HFNC on ventilation during an EBUS procedure under procedural sedation in patients with COPD gold class 3-4.