816 results
Our longstanding goal is to assess the clinical applicability of EIT in intubated and mechanically ventilated patients. We aim to observe changes in regional lung ventilation during alterations of mechanical ventilation strategies in clinical…
The aim of this study is to estimate the prevalence of late-onset inherited Pompe disease in a large cohort of patients with recently diagnosed obstructive sleep apnea syndrome (OSAS) in two different centres across Europe.
The primary objective of this Phase 3 extension study will be to obtain essential long term safety data to augment the overall safety database. The secondary objective will be to augment the efficacy information collected in the double-blind study (…
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…
The primary objective of the study is to evaluate the long-term safety of reslizumab at a dosage of 3.0 mg/kg every 4 weeks for approximately 24 months in pediatric and adult patients with eosinophilic asthma as assessed. The secondary objectives of…
1. To investigate whether an adjusted mode of APAP can improve patients adherence in comparison to fixed CPAP in present-day PAP therapy of OSAHS patients.2. To investigate the agreement between the parameters of the CPAP devices and the polygraphy…
To evaluate the value of volatile organic compounds analysis by eNose in the early detection of second primaries or metastasis (and early lesions).
The objective of this pilot study is to demonstrate that NAVA ventilation is superior compared to pressure support and pressure control ventilation in work of breathing (expressed as pressure-time product) patient ventilator synchrony and other…
The primary objective is a) to study the occurrence of recurrent wheezing following hospitalisation for severe RSV LRTD, and to study the differences in occurrence between ventilated and non-ventilated infants, and ) to study differences in lung…
To assess the validity, reliability and responsiveness of the LRTI-VAS in non-cystic fibrosis bronchiectasis.
Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…
(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…
Primary:To investigate the intravenous pharmacokinetics of [14C]-GSK2239633 in healthy male subjectsTo compare total radioactivity (drug-related material) in plasma relative to parent plasma concentrationTo determine total radioactivity (drug-…
Validate a new activity monitor in both healthy subjects and in patients with moderate to very severe CHF or COPD.
The purpose of this study is to explore and expand the understanding of the patient's experience of physical limitations in COPD from the perspective of the patient. The information will be used to support the development of a conceptual model…
The primary objective is to identify biomarkers measured in donor and recipient blood before lung transplantation which can predict lung graft function after lung transplantation. When the risk of PGD can be predicted, more adequate therapy can be…
Primary Objective: In 2 study groups, patients with COPD and patients with chronic heart failure:• To investigate whether, in comparison to unaided walking, the increase in 6 minute walking distance (6MWD) using a walking bike is greater than the…
To determine whether SRT achieves a local control rate comparable to surgery in patients with metastatic lung disease.
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
To evaluate the mechanism of action and effecacy of the Lung Volume Reduction Coil to improve QOL pulmonary function for homogeneous emphysema subjects with severe hyperinflation.