50 results
The primary objective of the study is as follows:· To compare the rate of asthma exacerbations between patients with low baseline periostin levels (< 50 ng/mL) and patients with high baseline periostin levels (* 50 ng/mL), as measured by…
The aim of the basic research in the laboratory is to develop new treatments to repair large bone defects, repair cartilage defects or inhibit the progression of osteoarthritis (cartilage degeneration). We focus on the following questions:1.How can…
Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.
Single Ring Optical Catheter illumination study in patients with obstructive Sleep Apnea during DISE
Primary objective of the study is to create one or multiple light ring(s) in the upper airway of OSA patients by means of Single Ring Optical Catheter(s), visualize and record these light rings with a DISE endoscope, capture the change of light ring…
The purpose of this pivotal study is to demonstrate long-term safety and efficacy of hypoglossal nerve stimulation to treat obstructive sleep apnea (OSA) using the Inspire II system and to support market release in the United States, Europe and…
The primary objective of this study is to analyze synchrony between ventilator and upper airways in COPD patients.Secondary objectives are to investigate whether the level of support and the triggering mode of noninvasive ventilation induces or…
Primary Objective(s):Find the best 2 or 3 step strategy for screening of OSAS in a Dutch employee population to optimize a large scale screening program. Home PSG with the ALICE PDX, combined with answers on sleepiness, is the gold standard. This…
Investigate the prevalence of rhinosinusitis and/or nasal polyps in adult patients with Cystic Fibrosis. Also several aspects of sinonasal disease are investigated; quality of life, correlation between phenotype and genotype, microbiology, anatomy…
The aim of this study is to estimate the prevalence of late-onset inherited Pompe disease in a large cohort of patients with recently diagnosed obstructive sleep apnea syndrome (OSAS) in two different centres across Europe.
1. To investigate whether an adjusted mode of APAP can improve patients adherence in comparison to fixed CPAP in present-day PAP therapy of OSAHS patients.2. To investigate the agreement between the parameters of the CPAP devices and the polygraphy…
The purpose of this pilot study is to evaluate the feasibility, efficacy, safety of and patients* compliance to an OA-CPAP for planning a main randomised controlled study. The main objective is to investigate if a patient is treated effective,…
1. To assess prevalence of SAS in a Dutch chronic heart failure (CHF) population. 2. To assess whether there are group differences between CHF-patients without SAS and CHF-patients with SAS (OSAS and CSAS). 3. To assess the validity of the ApneaLink…
The first objective of this study is to evaluate by direct laryngo-tracheoscopy the possible role of cuffed versus uncuffed tracheal tubes in producing airway injury in infants and children who were previously more than 24 hours intubated. The…
Feasibility study of the option NAVA (Neurally adjusted ventilatory assist) on the Servo-i in ventilated children in the age of 0-18 on the PICU and the NICU of the Erasmus MC -Sophia Childrens hospital in Rotterdam.
Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…
* To study systemic inflammation in individuals who are or are not susceptible to develop COPD. * To characterize the switch to chronicity of the systemic inflmmatory response in COPD* To determine whether the type and severity of the systemic…
The primary objective is to evaluate the percentage of the study population who have OSAS before and after treatment and the severity of it. A second objective is to correlate the prevalence of OSAS with different tumour sites and stages, as well as…
Primary aim is to study electronically measured compliance to inhaled corticosteroids (ICS) in a multicultural population of children with asthma in Amsterdam. A secondary aim will be to compare electronical data on compliance with parent reports.
Evaluation of the effect of positional therapy with the SPT Wave on sleep apnea severity, i.e. re-duction of the apnea-hypopnea index (AHI).
In this research we want to determine whether patients prefer the ProTrach DualCare over other speaking valves, if it improves quality of life, compliance with HME use and lung function.