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The effects of treatment on the right ventricular exertional contractile reserve in chronic tromboembolic pulmonary hypertension patients

The aim of this study is to evaluate the effects of treatment on the exertional contractile reserve and RV-arterial coupling during exercise in CTEPH patients. Furthermore, we evaluate the effects on the exertional contractile reserve and RV-…

Dyspnoea in Pulmonary Arterial Hypertension: Targeting the Diaphragm muscle

PRIMARY OBJECTIVE:To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of CTEPH patients SECONDARY OBJECTIVES:1. To determine whether diaphragm muscle fiber weakness is part of a generalized muscle…

Exercise-induced left ventricular diastolic dysfunction in COPD patients with a symptomatic limitation to exercise

The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…

Structural and Functional Microcirculatory Aspects of Patients with (suspected) Connective Tissue Disease and Pulmonary Arterial Hypertension

The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…

Gallium-67 scintigraphy in right ventricular disease

To study whether inflammmation plays a role in patients with RV disease, and can be detected with Gallium-67 scintigraphy

Restoration of cardiac function and regional pulmonary blood flow in chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy assessed during exercise by magnetic resonance imaging

To assess, by use of MRI measurements during exercise, the level of restoration of cardiac function, and to study whether excercise limitation in CTEPH patients after a hemodynamically succesful PEA is caused by an impaired RV stroke volume response…

Pulmonary hypertension in sarcoidosis: optimizing the diagnostic approach

The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…

Combined Pressure and Doppler Flow Velocity Assessment In Pulmonary Hypertension

In this explorative study, we aim to investigate whether MVR obtained with Doppler flow velocity, is a better predictor of adverse outcome than PVR obtained with Swan-Ganz measurements.

Neurological Monitoring during pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA) for chronic thrombo-embolic pulmonary hypertension (CTEPH)

To evaluate post-operative neurologic damage using clinical data on delirium and neuropsychological testing for long term postoperative decline, in combination with measures of NfL, GFAP and Tau in CTEPH patients treated with PEA or BPA in the…

Biomarker activity in adult patients with pulmonary hypertension.

The aim of this project is to evaluate the clinical value of biomarkers in adult patients with pulmonary hypertension, in particular:1) To quantify biomarkers of neurohormonal activity as NTproBNP, endotheline-1 and of immunological activity as CRP…