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Pharmacokinetic and pharmacodynamic modelling of routinely used off label drugs in premature neonates

Recently, population PK/PD modeling and simulation studies have enabled the development of evidence-based individualized dosing schemes for children with a limited number of subjects, thus improving drug safety and efficacy. The application of PK/PD…

Reducing Apneas in Preterm Infants: Low-Flow versus Caffeine

The main objective of this study is to determine if Low-Flow is non inferior in reducing apneic spells compared to caffeine. Secondary objectives are investigating if these treatments have an effect on the need of supplemental ventilation and on the…

PEEP resuscitation in preterm neonates, a double blinded, randomized, controlled trial comparing 5cmH2O and 8cmH2O PEEP.

In this multicenter trial we compare resuscitation of preterm neonates with either 5 cm H2O PEEP or 8 cmH2O PEEP. We think resuscitation with 8 cmH2O PEEP results in a better outcome compared to resuscitation with 5 cmH2O PEEP.

Positive end-expiratory pressure levels during resuscitation of preterm infants at birth

The specific trial aim is to establish whether the use of a high, dynamic 8-12 cmH2O PEEP level strategy to support the lung during stabilisation at birth, compared with a static 5-6 cmH2O PEEP level strategy, increases the rate of survival without…

Immediate Stimulation to Prevent and Inhibit cardiorespiratory Events in preterm infants

Evaluate the safety and feasibility of providing automated tactile stimulation in response to apnea, bradycardia and/or desaturation using the BreatheBuddy.

oxIdative stress in late preterM and term newborns with Persistent pulmonAry hypertension in the neonatal intensive Care uniT (IMPACT-study)

To investigate oxidative stress levels in the plasma and urine of late preterm and term newborns treated for PPHN in the NICU.

Multicenter study of the performance of Fabian-PRICO for saturation targeting routine use in the NICU

Investigate whether, in a routine clinical environment across a number of centers, the fabian-PRICO can adequately maintain oxygen saturation, with minimal staff intervention.

Safety and feasability of Predictive Intelligent Control of Oxygenation (PRICO) on the Neonatal Intensive Care Unit (NICU)

To test the safety and feasibility of a closed loop controller of the FiO2 based on the measured SpO2 in a NICU setting.