141 results
The projects is divided in 3 aims: 1) To evaluate the regenerative capacity of lung-derived MSCs (LMSCs) from normal and emphysematous lung tissue and compare LMCSs to MSCs derived from other tissues2) To investigate the interaction of MSCs with the…
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
The primary objective for this study is to compare the level and time course of the patient work-of-breathing during PS ventilation with the work-of-breathing during SIMV-PS ventilation with a lower rate of breaths per minute delivered by the…
Therefore, the aim of the myAirCoach project is to develop and evaluate technologies that assist patients with asthma. To this purpose we developed a one year observational quantification campaign in which we will identify potentially relevant self-…
The primary objective is to assess the association between the EELV measured with RIP and EIT, and to graphically depict the changes in the pressure volume curve during stepwise decreasing the CDP in a recruited lung and correlate these with…
To determine the true prevalence of pneumonia in exacerbating COPD patients by low-dose CT
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
Different sampling methods have been used for respiratory microbiome analyses, including both invasive as well as non-invasive techniques. We would like to investigate if the results of the bronchoscopy are comparable with results from the nose swab…
To study the effects of varying amounts of air and patient position on oesophageal pressure measurements in children with and without lung injury.
Primary: to characterize the safety and tolerability of GSK3052230 in combination with chemotherapy regimens, to determine the MTD and to assess overall response rate in patients with stage IV or recurrent squamous NSCLC with FGFR1 gene…
1. Optimize breath collection settings for optimal use in children.2. Evaluate the use of breath biomarkers for the prediction of therapeutic response in asthmatic children.
The primary objective is to investigate the measurement properties of isometric, isotonic and isokinetic protocol to assess quadriceps muscle endurance in patients with COPD. Our secondary objective is to determine the relationship between…
The present study aims at comparing a ventilation strategy with a lower tidal volume and a higher respiratory rate with ventilation using a higher tidal volume and a lower respiratory rate in ICU patients without moderate or severe ARDS.
The primary objective is to study the level and time course of the end-expiratory lung volume during the individual incremental * decremental PEEP titration; the secondary objective is to study if there is a significant association between the end-…
The objectives of the study are to gain more knowledge on 1) the effect of the LVRC treatment on patient-based outcomes like physical activity, 2) the underlying physiological mechanism of the treatment, and 3) the predictors of response to the…
The aims of the current study are:1. Demonstrate that during noninvasive ventilation a patient with acute respiratory failure is in better synchrony with the ventilator during NAVA compared to PSV mode.2. Demonstrate that the Servo-i ventilator is…
To evaluate the safety and effecacy of the Lung Volume Reduction Coil to improve QOL pulmonary function for emphysema subjects with severe hyperinflation.
Primary objective: * To study differences in global lung aeration before and during spontaneous breathing during mechanical ventilationSecondary objective:* To study the work of breathing (WOB) under various pressure support (PS) levels in…
The objective of this pilot study is to demonstrate that NAVA ventilation is superior compared to pressure support and pressure control ventilation in work of breathing (expressed as pressure-time product) patient ventilator synchrony and other…
To evaluate the mechanism of action and effecacy of the Lung Volume Reduction Coil to improve QOL pulmonary function for homogeneous emphysema subjects with severe hyperinflation.