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The validity of performance tests, the 4 meter gait speed and the 5 repetitions sit to stand test, in patients suffering PF in daily clinical practice

Objective: The aim of this study is to assess the validity of the 4MGS and 5STS to determine the functional exercise performance of PF patients.

Bronchiolitis obliterans syndrome and other allo-reactive lung syndromes
after allogeinic hematopoietic stem cell transplantation
Is early prediction of bronchiolitis obliterans possible by using biomarkers possible?

In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.

Pilot study: Respiratory microbiome analysis by the IS-pro technology

Different sampling methods have been used for respiratory microbiome analyses, including both invasive as well as non-invasive techniques. We would like to investigate if the results of the bronchoscopy are comparable with results from the nose swab…

Spontaneous breathing and work-of-breathing in mechanically ventilated children

Primary objective: * To study differences in global lung aeration before and during spontaneous breathing during mechanical ventilationSecondary objective:* To study the work of breathing (WOB) under various pressure support (PS) levels in…

Study evaluating preference, satisfaction and ease of use of inhalers in COPD diagnosed patients

to assess patient's overall preference for the two inhaler devices in COPD patients after 2 weeks of dialy practice.

Prevalence, incidence and adherence of *difficult-to-treat* adult asthma in the Netherlands

Objective:1. To describe the prevalence and incidence of *difficult-to-treat* adult asthma in the Netherlands.2. To describe factors associated with adherence with pulmonary medication in patients with difficult-to-treat airway disease. 3. To…

Risk of developing asthma in preschool children with episodic viral wheeze referred to secondary care

The primairy objective of this study is to investigate how many children who where diagnosed with episodic viral weeze by a hospital-based paediatrican have astma at the age of 6-8 years. The secundary objective of this study is to examine the…

the feasibility and reproducibility of the MicroRint pulmonary function test in people with an intellectual disability, aged 50 years and older.

To determine feasibility and reproducibility of MicroRint pulmonary function testing in 50+ people with different levels of intellectual disability.

Prevalence of latex allergy among operating room employees in the Netherlands

Research questions:What is the current prevalence of latex allergy among operating room employees from Erasmus Medical Centre, Rotterdam? Is the sensitisation prevalence significantly lower compared to the prevalence before introducing non powdered…

A 24-week randomized, controlled, multicenter, open-label study to evaluate the effect of reminder notifications and motivational/adaptive messaging on treatment adherence of COPD
subjects receiving Ultibro® Breezhaler® treatment using the Concept2 inhaler for dose administration and tracking

This study will evaluate the effect of dose tracking in conjunction with reminder notificationsand motivational/adaptive messages over 24 weeks on treatment adherence behavior insubjects with COPD. The dose tracking is done by the Concept2 inhaler…

Effects of neuromuscular blockade on transpulmonary pressure and diaphragm activity in paediatric moderate-to-severe acute respiratory distress syndrome: a pilot study

To test the hypothesis that NMBAs in mechanically ventilated children younger than 12 years of age with moderate-to-severe paediatric ARDS (i.e. oxygenation index > 12 and PEEP > 5 cmH2O despite adequate sedation) reduce the…

Respiratory timing during exercise

2.1 Primary Objective(s):The primary objective of this study is to determine whether analysis of breath-to-breath respiratory variability provides more information on the mechanism that is responsible for the RCP. Two hypotheses are tested: 1. After…

A multi-center, real-world exploratory cohort study to evaluate cough frequency, severity, and impact on quality of life in patients with non-idiopathic pulmonary fibrosis interstitial lung disease

The overall aim of this study is to assess the frequency, patient-reported severity and impact of cough, and the distribution of coughing fits during the daytime and nighttime, in a population of patients with non-IPF ILDs.Primary objective: The…

A randomized, multi-center, open-label, cross-over study comparing critical errors, overall errors, training/teaching time, and preference attributes of the ELLIPTA dry powder inhaler versus the BREEZHALER dry powder inhalers, in adult participants with mild to moderate asthma.

Primary objective:To compare the proportion of participants who make at least one critical error after reading the section on inhaler use in the patient information leaflets (PILs) for ELLIPTA and BREEZHALER inhalersSecondary Objectives:To compare…

Biological Investigation of Explanted Endobronchial Lung Valves study

The main objective of this study is to study and understand the underlying biological principles of granulation and fibrotic responses limiting the effectiveness and longevity of ELVR treatment with EBVs.

Calibration of Esophageal Balloon catheter in spontaneous and mandatory mechanical ventilation.

To obtain the best filling pressure of the Pes catheter in spontaneous mechanical ventilation, to obtain the esophagus elastance in spontaneous mechanical ventilation, and to compare the best filling pressures between the two modes (spontaneous and…