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Biomarkers in acute and chronic bacterial endobronchial infections in Cystic Fibrosis
A Pilot study

Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…

Assessment of central airways mechanics using Magnetic Resonance Imaging (MRI) and bronchoscopy: a comparison

We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…

Clinical evaluation of a new sweat test system in the diagnosis of cystic fibrosis after newborn screening

To determine the succes rate of the Nanoduct sweat test system.

COPD: Transition of systemic inflammation into multiorgan pathology (study 3).

To investigate in COPD whether: 1. systemic inflammation and multi-organ disease is more pronounced in more severe COPD2. quadriceps oxidative capacity and fiber type I proportion is reduced, and whether age, sex, smoking, physical activity, GOLD…

The Nanoduct study: a new sweat test system tested

To determine the reliability and feasibility of the Nanoduct sweat test system compared to the gold standard tests QPIT and Macroduct.

Acute and chronic inflammatory responses induced by smoking in individuals being susceptible and non-susceptible for development of COPD: from specific disease phenotyping towards novel made therapy (study 1).

• To define mediators involved in the early induction of COPD in susceptible smokers (and so to define new drug targets)• To develop new biological and clinical markers for the early diagnosis and monitoring of COPD• To characterize the switch to…

Air Trapping and Emphysema Changes During Respiration in Chronic Obstructive Pulmonary Disease.

1. To develop a method that lets us derive measures of air trapping and emphysema from static CT that are independent of inspiration level.In order to achieve this objective we need to:2. study the influence of inspirational level on the extent of…

Multiple Breath Washout to measure lung function in Congenital Diaphragmatic Herniation survivors between 5 and 18 years old

Our research project aims to answer 3 key questions:1. How do MBW, spirometry and body-plethysmography outcomes compare in survivors of CDH?2. What is the relation between MBW outcomes in survivors of CDH and age?3. Are prognostic factors of the…

Congenital Lung Abnormalities on MRI

Our main objective is to validate a MRI scan protocol for imaging parenchymal abnormalities in CPAM and describe the appearance of these abnormalities on MRI. Furthermore, we want to image postoperative changes in developing lungs of patients…

A clinical imaging study using [18F]F-AraG PET to visualize Tumor infiltrating T-cell Activation in Non-small cell lung cancer

• To perform full kinetic modeling of [18F]F-AraG for the uptake in tumor lesions and healthy organs (e.g. spleen) by exploring different kinetic models and outcome measures as well as its test-retest (TRT) variability to guide the selection of an…

Tracheomalacia in babies after correction of Esophageal Atresia - A First step to reduce respiratory morbidity

The main objective is to research the practicability of postoperative fLTB through the endotracheal tube, right before/during planned extubation in the intensive care unit (ICU) in newborn babies after EA correction.

Advanced Imaging in Chronic Pediatric Pulmonary Disease (CPPD)

Primary Aim: to validate 3D Spiro MRI against PCD-CT for accurate phenotyping and sensitive monitoring of children with CPPD, by assessing disease severity in term of regional lung structural and functional changes compared to PCD-CT.Secondary aim(s…