29 results
Primary Objectives: To investigate the pharmacokinetic interaction of elexacaftor/tezacaftor/ivacaftor and tacrolimus in adult CF patients using tacrolimus after renal or liver transplantation by:- quantitating the effect of elexacaftor/tezacaftor/…
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.
The main objective is to research the practicability of postoperative fLTB through the endotracheal tube, right before/during planned extubation in the intensive care unit (ICU) in newborn babies after EA correction.
Primair eindpunt:Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis (CF) Who Are Homozygous or Heterozygous for the F508del Mutation.Secundair eindpunt:Evaluate the long-term efficacy of VX-…
This study aims to evaluate the PK profile and IIV of drug exposure in plasma in children (aged 6-17 years) receiving (elexacaftor-)tezacaftor-ivacaftor. Secondary objectives are to evaluate the relationship between covariates and PK parameters that…
Our overall aim is to assess the seroprevalence of SARS-CoV-2 antibodies in an international population of pwCF and to examine associations between SARS-CoV-2 infection and clinical risk factors for infection, as well as subsequent clinical outcomes…
Primary objective: To compare the exposure of ETI in a group of pwCF with the highest decrease in sweat chlorid and the lowest decrease in sweat chloride as result of ETI therapy.
Primary Aim: to validate 3D Spiro MRI against PCD-CT for accurate phenotyping and sensitive monitoring of children with CPPD, by assessing disease severity in term of regional lung structural and functional changes compared to PCD-CT.Secondary aim(s…
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age