71 results
To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.
(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…
We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Primary Objectives:- Evaluate changes in the immune system upon exposure to FVIII in patients with severe hemophilia A - Identify immunologic predictors of FVIII inhibitor development or tolerance
To assess the ex vivo cytokine production of whole blood during 28 days after phlebotomy (routine withdrawal of 500 ml of blood).
To define the role of genetic variations in SNARE protein genes in the regulation of VWF plasma concentrations and their effect on other substances secreted by WPBs and alpha-granules and coagulation parameters under physiological circumstances.
To determine whether pathological changes are visible in brain parenchyma, blood vessels or other intracranial structures on ultra high field MRI in SCD patients in normal anatomical areas on 3.0 Tesla MRI and to determine the nature of these…
The aim of the study is to understand the effects of CPB on coagulation and fibrinolysis to improve treatment of excessive blood loss (>2L/24 hours or >200 mL/hour) after cardiac surgery.The objective of this study is to differentiate…
Main objective of the current study is to evaluatie clinical, laboratory and genetic risk factors associated with prograssion of neurological damage. The final objective is to make a prognostic model of these risk factors to predict early…
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
The primary objective of this study is to establish a panel of markers that can be used for further research into the understanding of the pathogenesis of PTS.
The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
Our principal aim is to assess the effects of phlebotomy on aortic augmentation (AIx) and central BP in supine position and after standing; second, to assess the effects of counter maneuvers (leg crossing and thigh compression) on aortic…
To study the effect of different treatment modalities, in newly diagnosed ITP patients, on disease activity, platelet activity, the results of the MAIPA, and the relation between these.
- To gain insight in dynamics of PTX3, bonemarkers PYD, DPD and zinc during admission for sickle cell painful crisis.- To correlate the above markers with clinical parameters of severity of painful crisis (pain score, the occurrence of…
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim of this study is to characterize the early immune response against F VIII concentrates in patients with severe hemophilia A before and during inhibitor development.