15 results
The objective of ths study is to investigate whether use of Tranylcypromine, a monoamine oxidase inhibitor, results in increased expression of HbF in adults. If this is the case, we will use the results of this study to design follow-up research…
To determine whether pathological changes are visible in brain parenchyma, blood vessels or other intracranial structures on ultra high field MRI in SCD patients in normal anatomical areas on 3.0 Tesla MRI and to determine the nature of these…
Main objective of the current study is to evaluatie clinical, laboratory and genetic risk factors associated with prograssion of neurological damage. The final objective is to make a prognostic model of these risk factors to predict early…
- To gain insight in dynamics of PTX3, bonemarkers PYD, DPD and zinc during admission for sickle cell painful crisis.- To correlate the above markers with clinical parameters of severity of painful crisis (pain score, the occurrence of…
STUDY OBJECTIVESTo determine whether NAC therapy results in decreased red cell PS exposure, endothelial activation, inflammation, and reduction clotting activation in the steady state.
1. To establish the prevalence of PH in our population of children with SCD by standardized echocardiography; 2. To investigate the predictive value of alveolar and bronchial FeNO for PH in SCD patients. 3. To establish (genetic) risk factors for PH…
Aim of the study is to answer the following questions:1. Is cerebral autoregulation impaired in SCD compared to historical control groups and published standard values?2. Do patients with a high level of steady state haemolysis have a more impaired…
In this study the cumulative incidence and the clinical and immunogenetic determinants of allo-antibody formation in SCD patients in response to RBC transfusion will be evaluated.
To investigate whether serum alemtuzumab concentrations are predictive of the robustness of engraftment in SCD patients undergoing a matched sibling donor transplantation with alemtuzumab/TBI conditioning resulting in mixed chimerism.
In this study, the genetic risk factors and time dependent risk factors for alloimmunization will be analyzed. Furthermore, the role of the innate and adaptive immune system on allo-antibody formation in SCD patients will be elucidated.
To assess what the survival of transfused red blood cells (RBC) is in patients with sickle cell disease and *-thalassemia.
The aim of this study is to get more insight in the pathogenesis of (P)SCR by comparing: (1) Red cell characteristics (deformability and point of sickling in hypoxia measured by the Oxygenscan), (2) Angiogenesis by determining several biomarkers of…
To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease.
To determine the natural history of sickle cell disease and to identify modifying factors, including: (epi)genetic, biological, pathophysiological, social/ demographic, psychological and therapeutic determinants, which contribute to morbidity and…
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…