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SOAR Trial Interventional phase II single-arm study to assess efficacy and safety of Eltrombopag combined with cyclosporine as first line therapy in adult patients with severe acquired aplastic anemia.

Primary: To evaluate the efficacy of eltrombopag + cyclosporine as first-line therapy on overall hematologic response (neutrophil, platelet, hemoglobin) by 6 months.Secondary: Overall hematologic response (neutrophil, platelet, hemoglobin) by 3 and…

A Phase 1b/2 Study of the Dual MDMX/MDM2 Inhibitor, ALRN-6924, for the
Prevention of chemotherapy-induced Myelosuppression

Phase 1b:Primary:- To evaluate the safety and tolerability and determine the recommended Phase 2 dose (RP2D) and schedule of ALRN-6924 when administered to patients with TP53-mutated extensive disease (ED) small cell lung cancer (SCLC) receiving…

The Effects of Transfusion of Red blood cells In the critically ill II

To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.

Bleeding in patients with hemato-oncological disease in relation to platelet function (BOP study)

To assess the relation between bleeding tendency (patients with WHO grade II or more) and platelet function and platelet /count in patients with hemato-oncological disease

Assessing the fractional absorption of iron from edible insects

The primary objective is to assess the relative bioavailability of iron from insect added to either a high- or low-phytate meal in humans and its potential to provide bioavailable iron. The secondary objective is to determine whether addition of…