10 results
We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.
To study the effect of different treatment modalities, in newly diagnosed ITP patients, on disease activity, platelet activity, the results of the MAIPA, and the relation between these.
Aim of the study is to investigate the correlation of levels of cleaved protein S and protein S activity with platelet count and levels of markers for platelet destruction
1. To study the mechanisms that control endothelial and platelet secretion using blood outgrowth endothelial cells (BOECs) as an ex vivo model of endothelial and platelet secretion, in order to identify new regulators of and further unravel their…
The main objective is to determine genetic phenotype and the prevalence of anti-HLA (human leucocyte antigen) and anti-HPA (human platelet antigen) antibodies in patients with Glanzmann thrombasthenia.
Recent data shows that patients with ITP have increased levels of the so called platelet-extracellular-vesicles (EVs). In this pilotstudy we would like to characterize these EVs and investigate whether they play a pathogenic role in the maintenance…
Investigate the relationship between disease activity in ITP and the phenotype and function of autoantigen-specific T cells and B cells.
Primary Objective:Part 1: to characterize platelets of patients with Lowe syndrome using superresolution microscopy.Part 2: to characterize platelet age in patients receiving chemotherapy for AML using artificial intelligence techniques.Secondary…
To evaluate the long-term neurodevelopmental outcome in two groups of children with FNAIT. First, children with unanticipated disease *index cases* that were born without maternal IVIg administration during pregnancy. Second, children with…
The aim of this study is to characterize the in vitro properties of platelets and autoantibodies of adult patients with primary/chronic ITP, in order to gain insight in the molecular mechanisms underlying the disease. This may lead to development of…