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Central Hemodynamics, Augmentation index and Microcirculation after Phlebotomy

Our principal aim is to assess the effects of phlebotomy on aortic augmentation (AIx) and central BP in supine position and after standing; second, to assess the effects of counter maneuvers (leg crossing and thigh compression) on aortic…

Determining the role of Von Willebrand factor and ADAMTS13 in the adhesion of sickled erythrocytes to endothelial cells

To determine the role of VWF and ADAMTS13 in the adherence of sickled erythrocytes to vascular endothelium.

Sickle Red blood Cell Survival: explaining heterogeneity

To examine the determinants of survival of donor RBCs in SCD patientsTo look into the effect of transfusion on the innate immune system of sickle cell patients, in particular, the phenotype of the neutrophils.

Investigating the interplay between iron (overload) and erythropoiesis in rare hereditary anemias.

Investigate regulators of (disturbed) iron homeostasis and cellular determinants of iron overload in RHA. to decipher crucial elements of the crosstalk between iron metabolism and erythropoiesis