29 results
Investigate regulators of (disturbed) iron homeostasis and cellular determinants of iron overload in RHA. to decipher crucial elements of the crosstalk between iron metabolism and erythropoiesis
Primary objectives:- to explore transfusion induced differences in vital (activity) parameters such as heart rate, respiratory rate and activity before and after RBC transfusions in regularly transfused patients using the pinpointIQ* system.- To…
To study the effect of crizanlizumab on the hemodynamics of the cerebral vasculature (CBF and CVR)
To evaluate whether the RBCs derived from WB and processed with the Reveos system using the non-DEHP disposable sets meet the US criteria for 24-hour recovery after 42 days of storage.
Primary objective: To assess the feasibility of donor screening, collection, production and storage of sufficient CB-RBC products to potentially meet the transfusion need in extremely preterm neonates.
Objective: Primary objective: Red blood cell aggregation and elongation (deformability) assessed by a laser assisted optical rotational cell analyzer (LORCA) on days 1-3, and within 24 hours after weaning of ECLS. Secondary objectives are red blood…
CORE PERIODPrimary:* Evaluate the safety and tolerability of up to 24 weeks of AG-348 administration in patients with pyruvate kinase deficiency (PK deficiency).Secondary:* Evaluate the pharmacokinetics (PK) of AG-348 and the metabolite AGI-8702.*…
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
Primary aim:- What is the increase in hemoglobin concentration between epoetin alpha injection number three and four in patients awaiting orthopedic surgery?Secondary aim:- What is de increase in hemoglobin concentration between epoetin alpha…