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Dihydropyrimidine dehydrogenase (DPD) deficiency and haematological abnormalities

To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.

Thyroid hormone metabolism and innate immunity: the role of deiodinase type 3 in polymorphonuclear leukocytes

The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.

Cytokines, autoantibodies and astrocytes in the pathology of Aicardi-Goutieres syndrome (AGS)

The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…

Functional investigation of a variant in ARGHAP18 in a family with mastocytosis

To investigate the functional consequences of the found variant in ARGHAP18 in mast cell behaviour.

Post-traumatic dysfunction of the innate and adaptive immune system and its relationship with the development of infectious complications in severely injured patients (POSEIDON study)

We expect to provide evidence for our hypothesis stating that patients who develop infectious complications after trauma are characterized by a specific subset of circulating neutrophils displaying a reduced capacity to eradicate bacteria.…