19 results
The primairy objective of this fase II study, is to compare two treatment regimens of vismodegib in two populations of patients with multiple BCC's (patients with Gorlin syndrome and patients who do not have Gorlin syndrome). Primary to assess…
The aim of this study is to investigate whether infiltration of the upper eyelid with Citanest is less painful then infiltration of the upper eyelid with Xylocaine. If this hypothesis proves to be correct, then in the future Citanest can be used in…
The primary objective of this study is to demonstrate the non-inferiority of AttraX® Putty as a bone graft substitute for autograft in instrumented posterolateral fusion of the thoracolumbar spine, in terms of efficacy and safety.
To compare the efficacy and safety of lenalidomide versus placebo maintenance therapy (standard care).
The primary objective of this study is to assess if cannabinoids modulate sweet taste intensity and liking.
To study the feasibility of applying tDCS to APD subjects to a) influence prefrontal asymmetries and b) assess whether the restoration of prefrontal electrophysiological balances is reflected in improved social-behavioral performance.
To define the optimum laparoscopic hiatus hernia repair, ensuring long-term effect with minimal postoperative side effects.
We aim to compare the clinical performance of zirconia stock and CAD-CAM produced implant abutments (experimental group) after one year of function. After one year, the abutments and crowns are removed and subjected to a static bending test in vitro…
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…
Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…
To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected subcutaneously by jet-injection to that of the same insulin injected with a conventional pen in the management of…
We propose to conduct a study in healthy subjects where a serotonergic challenge is given in a placebo-controlled, crossover fashion. Before each challenge, participants will be measured 1 time to define their baseline resting state networks (RSNs)…
To investigate if there is a clinically important different effect of atropine on haemodynamic variables, tissue oxygenation or microcirculation during anaesthesia with either sufentanil and propofol or with remifentanil and propofol.
The primary objective of this study is to measure the effect of a psychopharmacological manipulation of NE on fMRI measures of the fidelity of cortical representation.The secondary objective is to determine if increased levels of cortical…
The aim of this study is to investigate the effect of different doses of vitamin D on postprandial leukocyte activation markers, oxidative stress and arterial stiffness in vitamin D deficient females.
The aim is to assess if people can perceive if the exposure-unit is on or off.
The current research proposal is designed to assess the influence of cocaine on creativity.
Compare sensitivity and specificity of both rules as well as compare the accuracy between observer groups for these rules. Also the interobserver agreement is assessed to test whether the rules are reproducible.
The primary objective of this study is to compare pain suppression in two groups of subjects with chronic unilateral limb pain as a result of FBSS. Low Frequency spinal cord stimulation settings and High Frequency spinal cord stimulation settings…