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Influence of a fatty beverage (Milk) on the absorption of erlotinib: a randomized, cross-over pharmacokinetic study (MERLOT-study)

In this study we want to determine the erlotinib concentrations in blood after administration of erlotinib with water or whole milk with and without an antacid .

Influence of an acidic beverage on the absorption of erlotinib

To determine the influence of the acidic beverage Coca-Cola, concomitantly taken with erlotinib (with or without a PPI), on erlotinib plasma pharmacokinetics compared to erlotinib concomitantly taken with water in cancer patients.

Effect of Esomeprazole on the Pharmacokinetics of BMS-275183 in Patients with Advanced Malignancies

Primary Objective: To assess the effect of esomeprazole on the pharmacokinetics of BMS-275183. Secondary Objectives: To evaluate the safety and efficay of BMS-275183 co-administered with esomeprazole.

An open-label, non-randomized, fixed-sequence crossover study to investigate the effects of the proton pump inhibitor esomeprazole on the pharmacokinetics of elinzanetant (BAY 3427080) as well as assessment of the absolute bioavailability of elinzanetant using a single intravenous microtracer dose of [13C5]BAY 3427080 in male and female healthy participants.

Elinzanetant is an investigational compound. It is not approved for sale. That means it can only be used in studies like this one. Elinzanetant has been extensively tested in the laboratory. It has also been already administered to approximately 300…