Search for a trial

The effect of insulin-induced hypoglycemia on brain lactate accumulation and regional cerebral blood flow, an explorative study

The primary objective of this study is to investigate the effect of hypoglycemia on brain lactate accumulation and regional cerebral blood perfusion in humans. The secondary objective is to assess whether this effect is a related to hypoglycemia…

Open Label Single Period Pilot Clinical Trial to Standardize Procedures for Evaluation of Glucose Dependent Insulin Secretion in Subjects with Type 2 Diabetes Mellitus

To standardize the procedures and analyses to support evaluation of glucose dependent insulin secretion in Type 2 Diabetes Mellitus in subjects with Type 2 Diabetes.

Pharmacology of rapid-acting insulin injected by needle-free jet-injection in patients with diabetes

To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected with jet-injection to that of the same insulin injected with a conventional pen prior to a standardised meal.

The effect of rapid-acting insulin injected by needle-free jet-injection in the management of hyperglycemia in patients with diabetes

To compare the pharmacokinetic and pharmacodynamic profile of the rapid-acting insulin analogue aspart (Novorapid®) injected subcutaneously by jet-injection to that of the same insulin injected with a conventional pen in the management of…

An open-label, crossover study to assess the pharmacokinetics, safety and tolerability of pulsatile intra-vaginal delivery of insulin aspart in females with diabetes mellitus type 1

Primary* To explore the pharmacokinetics of insulin aspart after pulsed intra-vaginal delivery using the MedRing and after subcutaneous injection in women with DM1.Secondary* To assess the safety and short-term tolerability of insulin aspart after…