116 results
The primary objective of this study is to identify biomarker fingerprints in patients with ulcerative colitis (UC) and Crohn*s disease (CD, that can indicate that an exacerbation has begun, although the patient still feels well. Ultimately, the…
Thermoregulation in patients with spinal cord injury and cold sensations, an explorative pilot-study
To investigate whether SCI patients with regular complaints of cold sensations in daily life have more impaired thermoregulatory responses to changes in environmental temperature compared to SCI patients who do not have these cold sensations in…
The primary objective of this study is to investigate if shear-wave elastography and contrast-enhanced ultrasonography can identify those patients most suitable fir an intervention (surgery or endoscopic balloon dilation) and those patients that…
To establish the point prevalence rate as well as the lifetime prevalence rate of sexual hallucinations in patients diagnosed with a bordeline personality disorder, and to establish the relation of these hallucinations with childhood trauma as well…
To assess PE rate and pouch characteristics in good and bad responders two years after LRYGB by MRI.
Primary objective:To compare migraine attack duration between menstrually-related migraine attacks and non-menstrually-related migraine attacks. Additional objectives:- To compare clinical characteristics between menstrually-related migraine attacks…
We aim to identify the predictive value of the candidate biomarkers suggested by the EAACI taskforce for response to AIT. Additionally, we aim to explore novel candidate biomarkers both for clinical follow up as well as contribute to unravelling the…
To evaluate DIT treatment outcome and possible predictors of treatment outcome in patients with MUSS To evaluate brain structure and function related to SSD pre-and post treatment.
We aim to investigate, for the first time, differences in frontal activation between healthy elderly people from Okinawa and the Netherlands. We predict that the Western European elderly will show an "MCI-light" pattern, whereas the…
This project aims to provide a deeper understanding of compensation strategies for gait impairments in PD. Specifically, the key objectives are: (1) To correlate the effectiveness of each type of compensation strategy to individual patient…
The aim of this in situ study is to investigate whether occlusal loading leads to increased secondary caries formation in loaded compared to unloaded samples in a near-clinical environment.
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
Assessing the post traumatic and degenerative radio-carpal osteoarthritis of open reduction and internal fixation compared with non-operative treatment for elderly patients with an intra-articular distal radius fracture.
1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…
Primary Objective: Further delineation of the natural history and phenotype/genotype relation of vEDS pateints with a heterozygous pathogenic variant in the COL3A1 gene. Secondary Objectives: 1. reasons for referral for genetic analysis; 2. all…
BIOMAP (Biomarkers in Atopic Dermatitis and Psoriasis) NL is part of the BIOMAP consortium, which is a EU-funded consortium through which various research projects will address three main unmet needs in AD and Pso with a broad impact on disease…
To investigate the relation between a preoperative abnormal iron status and packed red blood cell transfusion, adverse event and change in disability.To investigate the association of the individual preoperative iron status abnormalities (low iron…
Primary objective:To investigate in Adolescent and Young Adult (AYA) Head and Neck Cancer (HNC) survivors treated with unilateral radiotherapy 5-10 years before, the long-term vascular complications in terms of carotid wall changes (ultrasonography…
The main objective is to investigate whether the variant indeed cause mitochondrial dysfunction leading to the observed phenotype, including characterization of the pathophysiology.
The objective of this study is to rigorously assess the repeatability and predictability of influenza virus evolution by experimentally evolving human seasonal influenza viruses in ex vivo human airway epithelium (HAE) cell cultures.