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Natural History Study of CEP290-Related Retinal Degeneration

The primary objectives of this study are the following:* To prospectively characterize CEP290-related retinal degeneration and the clinical phenotype of participants with light perception to 20/50 visual acuity and with either compound heterozygous…

Implementation of intrapartum non-invasive electrophysiological monitoring: a pilot study.

To determine the workability of the non-invasive abdominal electrode patch for implementation in clinical practice.

Effect of surgery on foot function in the management of equinovarus foot deformity following stroke

Objective: The aims of this study are to explore the effects of foot and ankle surgery on the equinovarus foot deformity of patients after stroke in terms of foot function, walking abilities and social participation. Furthermore, the relationships…

Autologous hematopoietic stem cell gene therapy in RAG-deficient severe combined immunodeficiency: pre-phase study

The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…

A Prospective, Non-randomized, Consecutive Series, Multicenter, Post-Market Study to Evaluate the Clinical Outcome of Total Knee Arthroplasty Using Journey II BCS Total Knee System

The purpose of this study is to document the short-, mid- and long-term safety and efficacy of the Journey II BCS knee prosthesis. The goal of this study is to confirm the safety and efficacy of the Journey II BCS knee prosthesis by demonstrating…

Immunogenicity of Tumor Organoids derived from colorectal, gastric, gynaecological and non-small cell lung cancer, a Feasibility Study

Establish the immunogenicity of tumor organoids in vitro

Gaining insight into dual sensory loss - Quantitative study

The objective of this study is to determine which problems arise from different levels of impairments in visual and auditory functions. We will especially focus on the areas of access to information, communication, fatigue and mobility.

Long-term neurodevelopmental outcome after perinatal arterial ischemic stroke

The main goal of this study is to determine motor, cognitive, behavioral, executive, and language functioning of children with PAIS at school age. Furthermore, we will analyze the effect of PAIS on brain growth, development, and connectivity using…

beReady study: A study to identify potential healthy volunteers eligible for early phase vaccine trials in the context of pandemic preparedness

- To identify healthy volunteers that are able and willing to participate in future vaccine trials.- To install a pool of healthy volunteers ready to participate in vaccine research for infectious diseases.- To accelerate the set- up phase and…

Prevalence of unmet target LDL-C recommendations in very high risk patients despite high intensity lipid modifying therapy

To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…

Validity and reproducibility of practical performance-based tests to estimate aerobic capacity in patients scheduled for elective colorectal surgery

We aim to determine the validity of the steep ramp test as practical performance-based aerobic capacity test in patients undergoing elective colorectal resection by correlating the tests* scores with the ventilatory anaerobic threshold and oxygen…

Characterizing tissue protein synthesis rates of non-small cell lung carcinomas in lung cancer patients

The current study aims to recruit a greater number of lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to…

Longitudinal exploratory analysis of tumor-specific T-cell immunity and microbiome/calprotectin testing in patients with solid tumors

To study the effect of immune modulating therapies, including anti-CTLA4, anti-PD-1, anti-PD-L1checkpoint inhibitors, and TIL therapy, on the composition and activation of systemic and local immunity, with an emphasis on the size and diversity of…

The impact of eating rate of ultra-processed foods on dietary behaviour

The primary objective of this study is to determine the role of eating rate of ultra-processed food (14 day) diets in moderating ad libitum energy intake over time.

Effectively intervening in traumatized parents and children after structural domestic violence: A multiple baseline analysis

The goal of this study is to evaluate the effectiveness of an individualized treatment trajectory in which the order of trauma therapy for the parent, trauma therapy for the child and attachment-based therapy is tailored towards the complex needs of…

The Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics (AURORA) Household Plastics Study

Primary Objective: 1) To assess determinants of circulating MNP levels in Dutch females of reproductive age, including the relative contribution of indoor sources, food packaging and preparation methods to MNP and plastic-associated chemical body…

Validation of CPM#1 compressibility in healthy volunteers in rest and after exercise

The primary objective is - To clinically validate the inter-observer reliability of compressibility measurements with the CPM#1 device during rest in healthy volunteers.

pharmacoGenomic gUIDEd persONalized MEDicine: clinical setting

In this study, we aim to evaluate the impact of PGx-guided therapeutic management of hyperpolypharmacy patients using a multidisciplinary approach at Maasstad hospital.

Trial readiness and fitness for congenital myopathies: A 2-year prospective natural history study including a cross-sectional study on muscle fatigability

Part 1: Assess the natural disease course of three congenital myopathies during 24 months. This will enable us to obtain a detailed assessment of the phenotype and genotype, evaluate and optimize the current care, determine the rate of disease…

The representation of the breast on the somatosensory cortex after autologous breast reconstruction using 7 Tesla functional MRI

To study the neuroplasticity of the brain after mastectomy and breast reconstructive surgery by assessing the somatotopy of the breast on the somatosensory cortex of patients who underwent either breast reconstruction with and without nerve…