1551 results
The primary objective of the current project is to develop and test a real-time accurate neuro-mechanical model-based controllers of the lower limb The hypothesis are that the synergy-driven approach would adapt to changes in speed, the enhanced…
Primary objectiveDemonstrate that the SENSA Bladder Sensor can detect the bladder before urination among its adult intended user Secondary objective(s)1) Collect real-life data to evaluate the clinical performance of the SENSA Bladder Sensor, the…
To determine the effect of weight loss after bariatric surgery (BS) on different measures of cognition, brain function and structure investigated with various neuropsychological tests and studying various magnetic resonance imaging (MRI) parameters…
To evaluate Hex4 concentrations in CSF from patients with infantile-onset (IOPD) and late-onset (LOPD) Pompe disease
Objective: to investigate areas of uncertainty about a possible future pilot RCT using AF-EMDR as an add-on intervention in inpatients who use non-opioid drugs and receive regular, inpatient addiction treatment, by determining: Feasibility.…
This study aims to examine the effect of furosemide on renal PBUT excretion and PBUT plasma levels in patients with CKD.
Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.
The aim of SPIRIT is to investigate the mechanisms of the immunological tolerance to FVIII in patients with hemophilia A aged younger than 18 years using NFT for prophylaxis.
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age
The main aim of the current study will be to determine the metabolic fate of dietary protein. More specifically, the main aim is to assess the incorporation of protein-derived amino acids in a wide variety of organ tissues in vivo in humans.
To compare the plasma concentration versus time profiles and postprandial bioavailability of DHA and EPA after a nutritionally relevant oral dose of 1.1 gram (expressed as DHA + EPA) administered as either CCx gelatin-based soft chews (emulsified)…
Primary objective• To characterise natural disease progression rates of MRI- and/or US-assessed measures of muscle properties and muscle function and strength tests in children with neuromuscular disorders through standardized annual follow-up…
To investigate:Study 1. the influence of graft choice (hamstring v.s. quadriceps v.s. patellar tendon v.s. VKB repair) for ACLR on dynamic tibiofemoralmovements after an ACLR;Study 2. the influence of the anatomy of the knee on dynamic tibiofemoral…
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
The main objective is to assess the perceived sound quality of different speech and music excerpts that are modified using the dereverberation algorithm by CI users. To this end a suitable graphical user interface (GUI), the MuSHRA, will be…
In this study we aim to answer the question whether TCR diversity becomes limiting at older age and thereby leads to impaired responses to novel antigens. While many studies have suggested a contraction in TCR diversity with age, a one-to-one…
The primary objective of this study is to determine the femorotibial and patellofemoral weight bearing in vivo kinematics of Journey II BCS TKA patients and to determine correlations that the kinematics may have with patient-reported outcome…