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A prospective, randomized study comparing chemotherapy versus chemotherapy plus immunotherapy in patients with advanced non-small cell lung cancer with low TMB and oncogenic driver, STK11, KEAP1 or NFE2L2 mutation and a PD-L1 TPS

To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low TMB and either actionable mutation, inactivating STK11, KEAP1 or NFE2L2 mutations, treated by…

A prospective, multicentric, feasibility investigation to assess the
effect of the Tinnitus Implant System on tinnitus loudness in adults with moderate
to severe chronic tinnitus accompanied by normal hearing to moderately severe
hearing loss.

To assess the efficacy of the Tinnitus Implant System on tinnitus loudness in adults with moderate to severe chronic tinnitus accompanied by normal hearing to moderately severe hearing loss at 6 months post-activation of the Tinnitus Implant System…

ARIA

Primary objective: study the technical feasibility and safety to perform stereotactic radiotherapy on MR-linac for cT1-2 glottic cancer patients.Secondary objectives: monitor the patient safety, toxicity and tolerability of this…

2BEGIN

The primary objective of this study is to evaluate the diagnostic accuracy of physical examination and ultrasound to identify active synovial proliferation in haemophilia patients with subclinical synovial proliferation.  The secondary…

Feasibility of exergaming to reduce sedentary time in persons with an LVAD: The Heart-eXg LVAD-study

To determine the feasibility of tailored exergaming for persons with a LVAD (acceptability, the demand, the implementation, practicality, adaption, expansion, and perform limited-efficacy testing).