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Meaningful digital biomarkers for longitudinal monitoring of obstructive sleep apnea around diagnosis and during titration of treatment with CPAP or MAD

Primary Objective: Assess which digital health metrics are relevant to monitor for patients with (or highly suspected of having) obstructive sleep apnea before and after diagnosis, and during titration of treatment with continuous positive airway…

Implementing a new controlled human infection model with a novel Respiratory Syncytial Virus (RS virus) in healthy volunteers.

The main objective of the study is to establish a controlled human infection model (CHIM) for RSV for future drug and vaccine testing and to identify the inoculation dose needed to induce RSV infection with this new strain in 50-70% of exposed…