46 results
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
1. To determine biomarkers of response and non-response to treatment for active SLE in a prospective study where patients will be allocated to therapy according to current clinical practice and the EULAR guidelines (response biomarker study; 3TR SLE…
The aim of this project is to characterize the composition and activity of lymphocytes immune cell subsets and cholangiocytes in active inflammation in the central/extrahepatic bile ducts through surface markers and an in-depth transcriptomic…
To longitudinally evaluate the substantial differences in anatomical changes in the spine during adolescent growth in girls, at increased risk for scoliosis development, and in adolescent 22q11.2DS patients, that do and do not develop AIS.
The aim of the study is to map the changes that occur in breast tissue composition during pregnancy, lactation and post-lactational involution. The secondary aims are to:• validate the performance of diffuse optical spectroscopic imaging (DOSI)…
The primary objective is to determine if physical fatigability is present in infantile and young adult patients with FSHD.The secondary objectives are to determine if there is an association between fatigability ando Disease severityo Muscle…
Primary Objective: To identify disease (Parkinson*s disease) specific alterations in neural control of breathing by using respiratory neurophysiological techniques.
The current research project aims to improve the care of CABG patients, by a redefinition of PMI. In this research proposal, we focus on the diagnostic and clinical relevance of postoperative biomarker increases and will determine the association…
In this proposal, we therefore aim to characterize in detail the cutaneous B cell response in patients with isolated CLE (CLE only) and patients with systemic and cutaneous disease (SLE/CLE). Primary Objectives: 1. Characterize autoreactive B cells…
The primary objective of the study is to investigate if the VO2, Pressure Time Product, Work of Breathing and transpulmonary Pressure Swings predict weaning failure or extubation failure after een succesfull SBT.
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…
The main objective of this study is to evaluate the effect of anti-fibrotic/anti-SSc therapies using a SSc organ-on-a-chip (OoC) model. The secondary objectives of the study are:- To engineer an advanced OoC device to model SSc that incorporates key…
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
In this research proposal, we aim to develop chemical reporter molecules to study neutrophil activity and NET formation in real-time. We will systematically study the effect of brain-associated amyloid fibrils on NET formation and investigate the…
To identify novel (causal) risk factors, including biomarkers and genetic determinants for disease progression and (severe) diabetes complications in people with T2D, in order to develop new, more targeted and effective therapies that will improve…
To evaluate post-operative neurologic damage using clinical data on delirium and neuropsychological testing for long term postoperative decline, in combination with measures of NfL, GFAP and Tau in CTEPH patients treated with PEA or BPA in the…
As highlighted, significant gaps in knowledge remain regarding etiology of cough, consequences of cough and appropriate treatment of cough in patients with pulmonary fibrosis. A further understanding of the similarities and differences in cough…
The general objective of this study protocol is to add another follow-up measurement, round 8, to the Doetinchem cohort study, 6 years after round 7, and 36 years after round 1 This contributes to an infrastructure of data to tackle research…
To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.