339 results
Salmeterol has an inhibitory effect on both allergen and allergen/LPS induced inflammation in asthmatics while on maintenance treatment with low dose corticosteroids.
This international, multi-centre, double blinded, placebo-controlled, randomised clinical trial will be performed: To assess the effectiveness of one year of alternate days Levamisole treatment in a dose of 2.5 mg/kg in the prevention of relapses…
COMT and/or PRODH polymorphisms are debt to cognitive deterioration in velocardiofacial syndrome.
By using a surgical safety checklist, the incidence of postoperative complications will decrease.
To investigate the difference in effectiveness of methylphenidate (MPH) in the treatment of adult ADHD patients with and without comorbid cocaine dependence.
Pain (physical discomfort) and challenging behavior are highly prevalent in nursing home residents with dementia. It has been shown that pain is undertreated in this group, and that psychosocial interventions for behavioral problems are, allthough…
In the Netherlands over 10.000 patients are diagnosed with head and neck cancer or lung cancer every year of whom 25-50% have comorbid anxiety or depression. Is a stepped care strategy applied in an oncological setting more (cost-)effective to…
The objective of the study is to assess the impact of a proactive policy of offering EA at the start of labour before maternal request in women with a child in occiput presentation allowed to try a vaginal delivery, on maternal pain reduction,…
1. DCS enhances the speed and size of effect of exposure therapy in panic disorder and OCD; 2. This DCS enhancement is independent of the nature of the anxiety provoking situations (OCD-related versus panic-related); 3. There is no difference in…
This study aims to answer two research questions: 1. Does web-based monthly monitoring using the Asthma Control Test (ACT) improve asthma control? Is this strategy cost-effective? 2. Does asthma management guided by the fraction of nitric oxide in…
Hemodynamic optimization during and after colorectal surgery results in improved intestinal perfusion, sustained intestinal barrier and improved postoperative recovery.
Short-term cognitive behavioral therapy (CBT) given by primary health care workers with patients with chronic benzodiazepine use and new patients in the family practice with sleepinsdisorder, hypothised that CBT results in reduction of…
We hypoothesize that the effect that a single dose of montelukast has on exercise induced bronchoconstriction correlates with the effect it has after 8 weeks of treatment.
In this multicenter RCT we aim to investigate the quality of fracture reduction and fixation, and patient-relevant outcomes when using the intra-operative use of the 3D-RX-system as compared to the conventional 2D-fluoroscopy in patients with…
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
Because of a high cardiovascular disease (CVD) risk in people with FH, prevention of cardiovascular disease in people with FH is important for health gain and cost reduction. This randomised controlled trial (RCT) focuses on CVD risk reduction…
Treatment with Botox will give a better healing rate for anal fissures compared to treatment with isosorbidedinitrate ointment.
Presence of postural instability and gait dissorder PIGD (gait disorders, balance impairment, falls, fal-related injuries and FOG) are an important and disabling feature of idiopathic Parkinson’s disease (PD) where the level of functional ability is…
Multiple Endocrine Neoplasia type 1 (MEN1) and Von Hippel-Lindau disease (VHL) are rare autosomal dominantly inherited disorders characterized by the occurrence of various tumors. Therefore, mutation carriers undergo regular screening (yearly for…