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A randomized, open label, multi-center phase II study to compare bevacizumab plus RAD001 versus interferon alfa-2a and bevacizumab for the first-line treatment of patients with metastatic clear cell carcinoma of the kidney

• To estimate the difference in the efficacy and safety of RAD001 10 mg p.o. daily dose in combination with bevacizumab 10 mg/kg administered intravenously every two weeks for first-line treatment of patients with metastatic carcinoma of the kidney…

Predicited 3D-SAR coverage: a prognostic indicator for treament outcome in superficial hyperthermia for breast cancer recurrences at the chest wall?

The prime objective of the proposed study is to apply treatment modeling for superficial hyperthermia in a well-defined group of patients to investigate the potential of predicted 3-dimensional energy as source for a dose parameter that is…

A randomised, double-blind, placebo-controlled,
multicentre prospective dose-finding Phase II/III study
with atacicept given subcutaneously to subjects having
recently experienced a flare of systemic lupus
erythematosus (SLE)

PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…

Genetic regulation of stress responsivity as a risk factor for schizophrenia and bipolar disorder. ;Subtitle: The association of (epi)genetic factors on the hormonal and autonomic stress response after psychosocial stress

Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…

A study to evaluate the bioequivalence of Orfadin capsules 20 mg compared to Orfadin capsules 10 mg. An open-label, randomized, cross-over, single-dose study in healthy volunteers.

The primary purpose of the study is to investigate whether the new 20 mg capsule of Orfadin® (nitisinone) has a similar bioavailability in the body (gives the same concentration in the blood) as two of the marketed capsules of 10 mg. The secundary…

Effectiveness of eccentric calf muscle exercise therapy in patients with chronic midportion Achilles tendinopathy

To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.

Aspects of bracing in adolescent idiopathic scoliosis

Objective: The primary objective of the study is determining the contributing factors in  bracing for AIS. The contributing factors are determined as factors of influence in the  corrective possibilities and therefore end term…

Treatment Effect of Bone Anchored Protraction in Cleft Patients

Bone-anchored maxillary protraction therapy improves facial profile in cleft children.

Consumer Survey Mexico

The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.

The Shoulder Diary

Primary Objective  To describe how patients experience the first eight weeks after shoulder arthroplasty, regarding pain and pain medication, shoulder function and quality of life.  To determine the direct effect of patients' expectations on…

Study on shared decision making in choosing a treatment for pelvic organ prolapse

The use of an interactive web-based Decision Aid reduces decisional conflict and increases patient satisfaction with information and care.

Fluorescence visualisation during lymph node procedure in pediatric patients

The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…